Welcome to SEanalysis 2.0:   A comprehensive super-enhancer regulatory network analysis tool for human and mouse.

Introduction

We designed a novel web server, SEanalysis 2.0, which provides a comprehensive super-enhancers regulatory network analysis, involving the identification of SE-associated genes, TFs occupying these SEs and the upstream signaling pathways of idenfitied TFs. Users can perform the following SEs-associated analyses in the web server:
I. TF regulatory analysis.
II. Sample comparative analysis.
III. Pathway downstream analysis.
IV. Upstream regulatory analysis.
V. Genomic region annotation.

The current version of SEanalysis contains a total of 1,717,744 super-enhancers from over 2,670 Samples, including 1,739 human samples and 931 mouse samples; 10,710 TF ChIP-seq data for 1,468 human TFs and 446 mouse TFs generated from these cells/tissues; DNA-binding sequence motifs for 869 human TFs and 568 mouse TFs; as well as 2,880 human pathways and 1,487 mouse pathways. SEanalysis 2.0 provides risk SNP annotation to link super-enhancer with diseases/trait. SEanalysis 2.0 supports searching by either SEs, samples, TFs, signaling pathways or genes. Furthermore, the complex regulatory networks formed by these factors can be interactively visualized.

img-blur-shadow
Statistics
Sample Statistics
HumanMouse
Pathway The Number of Sources 10 2
The Number of Pathways 2880 1487
TF(ChIP-seq) The Number of Sources 5 1
The Number of TFs 1468 440
The Number of Samples 10 710 1051
TF(Motif) The Number of Sources 6 2
The Number of TFs 869 568
The Number of Motifs 3680 742
SE The Number of Sources 5 5
The Number of SEs 1167518 550226
Samples 1739 931
Live Statistics
For publication of results please cite the following article

Qian, F.C.*, Li, X.C.*, Guo, J.C.*, Zhao, J.M., Li, Y.Y., Tang, Z.D., Zhou, L.W., Zhang, J., Bai, X.F., Jiang, Y. et al. (2019) SEanalysis: a web tool for super-enhancer associated regulatory analysis. Nucleic acids research, 47, W248-W255.

SEanalysis 1.0 link is: http://www.liclab.net:8028/SEanalysis1/index.do

Sister Projects

The comprehensive human Super-Enhancer database

A web tool for super-enhancer associated regulatory analysis

An experimentally supported enhancer database for human and mouse

A comprehensive human chromatin accessibility database

A comprehensive database of human transcriptional regulation of lncRNAs

A resource for transcriptional regulation information of circRNAs

A comprehensive human gene expression profile database with knockdown/knockout of transcription factors

A variation annotation database for human

A comprehensive human lncRNA sets resource and enrichment analysis platform