Enhancers are distal cis-regulatory elements that drive lineage-specific transcription. Enhancers are essential for normal tissue and cell development. They also show strict disease, tissue, and cell-type specificity. Here, we present ENdb 2.0, an updated database built for specific diseases, tissues, cell types, cell lines, and exact validation experiments of enhancers.
The current release contains 5,402 manually curated enhancer evidence records, compared with 737 entries in ENdb 1.0, representing a 7.3-fold increase in database records. Among these, 3,448 records define enhancer–TF–target-gene relationships involving 496 TFs and 1,114 target genes. Compared with ENdb 1.0, TF and target-gene coverage increased by 1.9- and 2.9-fold, respectively. To provide more detailed biological context, ENdb 2.0 expands the annotation of tissues, cell sources, cell types and diseases. The current release covers 180 tissues, 1,114 cell sources, 415 cell types and 255 diseases. These annotations are linked to standard ontology terms and identifiers where available. We also expanded the curation of experimental evidence for enhancer function.
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