What is KnockTF?

We develop a comprehensive human and mouse gene expression profile database with TF knockdown/knockout (KnockTF), which provides a large number of available resources of human and mouse gene expression profile datasets associated with TF knockdown/knockout and annotates TFs and their target genes in a tissue/cell type-specific manner. The current version of KnockTF has 1093 manually curated RNA-seq and microarray datasets associated with 573 TFs disrupted by different knockdown/knockout techniques and across multiple tissue/cell types. KnockTF not only provides comprehensive gene expression information about target genes of TFs of interest, but also collects upstream pathway information of TFs and various functional annotation and analysis results of downstream target genes, including GSEA, GO enrichment, KEGG pathway enrichment, hierarchical clustering analysis and differentially expressed analysis. KnockTF further provides details about TFs binding to promoters, super-enhancers and typical enhancers of target genes. In the analysis section, a TF-differentially expressed gene network is constructed and used to perform network analyses for gene sets of interest, such as subnetwork location, topological analysis, TF enrichment analysis and TF upstream pathway analysis. KnockTF will help elucidate TF-related functions and tap potential biological effects.


Contact us

Principal Investigator: Chunquan Li, Ph.D.

The First Affiliated Hospital, Hengyang Medical School, University of South China

Email: lcqbio@163.com


We welcome researchers from all over the world to provide valuable advice for KnockTF, and make KnockTF more and more perfect.


Sister Projects

 TF-Marker
TF-Marker database for human

 TcoFbase
Document a large number of available resources of mammals TcoFs

 SEdb
SEdb: The comprehensive human Super-Enhancer databasebr

 SEanalysis
SEanalysis: a web tool for super-enhancer associated regulatory analysis

 ENdb
ENdb: An experimentally supported enhancer database for human and mouse

 VARAdb
VARAdb: A comprehensive human variation annotation database

 TRlnc
TRlnc: A comprehensive database of human transcriptional regulation of lncRNAs

 TRCirc
TRCirc: A resource for transcriptional regulation information of circRNAs

 ATACdb
ATACdb: A comprehensive human chromatin accessibility database

 LncSEA
LncSEA: A comprehensive human lncRNA sets resource and enrichment analysis platform