What is KnockTF?

We develop a comprehensive human and mouse gene expression profile database with TF knockdown/knockout (KnockTF), which provides a large number of available resources of human and mouse gene expression profile datasets associated with TF knockdown/knockout and annotates TFs and their target genes in a tissue/cell type-specific manner. The current version of KnockTF has 1093 manually curated RNA-seq and microarray datasets associated with 573 TFs disrupted by different knockdown/knockout techniques and across multiple tissue/cell types. KnockTF not only provides comprehensive gene expression information about target genes of TFs of interest, but also collects upstream pathway information of TFs and various functional annotation and analysis results of downstream target genes, including GSEA, GO enrichment, KEGG pathway enrichment, hierarchical clustering analysis and differentially expressed analysis. KnockTF further provides details about TFs binding to promoters, super-enhancers and typical enhancers of target genes. In the analysis section, a TF-differentially expressed gene network is constructed and used to perform network analyses for gene sets of interest, such as subnetwork location, topological analysis, TF enrichment analysis and TF upstream pathway analysis. KnockTF will help elucidate TF-related functions and tap potential biological effects.

Contact us

Principal Investigator: Chunquan Li, Ph.D.

The First Affiliated Hospital, Hengyang Medical School, University of South China

Email: lcqbio@163.com

We welcome researchers from all over the world to provide valuable advice for KnockTF, and make KnockTF more and more perfect.

Sister Projects

TF-Marker database for human

Document a large number of available resources of mammals TcoFs

SEdb: The comprehensive human Super-Enhancer databasebr

SEanalysis: a web tool for super-enhancer associated regulatory analysis

ENdb: An experimentally supported enhancer database for human and mouse

VARAdb: A comprehensive human variation annotation database

TRlnc: A comprehensive database of human transcriptional regulation of lncRNAs

TRCirc: A resource for transcriptional regulation information of circRNAs

ATACdb: A comprehensive human chromatin accessibility database

LncSEA: A comprehensive human lncRNA sets resource and enrichment analysis platform