Welcome to KnockTF
a comprehensive human gene expression profile database with knockdown/knockout of transcription factors
What is KnockTF?
We develop a comprehensive human gene expression profile database with TF knockdown/knockout (KnockTF), which provides a large number of available resources of human gene expression profile datasets associated with TF knockdown/knockout and annotates TFs and their target genes in a tissue/cell type-specific manner.
The current version of KnockTF has 570 manually curated RNA-seq and microarray datasets associated with 308 TFs disrupted by different knockdown/knockout techniques and across multiple tissue/cell types. KnockTF not only provides comprehensive gene expression information about target genes of TFs of interest, but also collects upstream pathway information of TFs and various functional annotation and analysis results of downstream target genes, including GSEA, GO enrichment, KEGG pathway enrichment, hierarchical clustering analysis and differentially expressed analysis. KnockTF further provides details about TFs binding to promoters, super-enhancers and typical enhancers of target genes. In addition, a TF-differentially expressed gene network is constructed and used to perform network analyses for gene sets of interest, such as subnetwork location, topological analysis and hypergeometric enrichment. KnockTF will help elucidate TF-related functions and tap potential biological effects.
Principal Investigator: Chunquan Li, Ph.D.
School of Medical Informatics,Daqing Campus Harbin Medical University 39 Xinyang Road, Daqing 163319, China
We welcome researchers from all over the world to provide valuable advice for KnockTF, and make KnockTF more and more perfect.