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T(co)F Overview
T(co)F: SMAD5
Species: Homo sapiens
Knock-Method: CRISPR
T(co)F Class: SMAD/NF-1 DNA-binding domain factors
T(co)F Superclass: beta-Hairpin exposed by an alpha/beta-scaffold
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR649MBU
Platform: -
Pubmed ID: 22955616

SMAD5- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of SMAD5
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of SMAD5

Upstream Pathway Annotation of SMAD5
T(co)F Pathway Name Source Gene Number
SMAD5
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Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) )
INOH 7
SMAD5
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Hs_Steroid_Biosynthesis_WP496_69016
WikiPathways 8
SMAD5
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Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) )
INOH 8
SMAD5
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ALK2 signaling events
PID 11
SMAD5
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Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) )
INOH 21
SMAD5
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Signaling by BMP
Reactome 23
SMAD5
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ALK1 signaling events
PID 26
SMAD5
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BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) )
INOH 34
SMAD5
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BMP receptor signaling
PID 42
SMAD5
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TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) )
INOH 51
SMAD5
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TGF-beta signaling pathway
KEGG 82
SMAD5
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TGF-beta signaling pathway
PANTHER 88
SMAD5
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Wnt signaling pathway
PANTHER 250
Target Gene Expression Analysis
Expression Atlas of SMAD5