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T(co)F Overview
T(co)F: RUNX2
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Runt domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: Natural Killer Cell
Tissue Type: Cord_blood
Biosample Type: Primary cell
# of Control: 5
# of Treat: 5
Data Source: GEO
Profile ID: GSE172435
Platform: GPL18573
Pubmed ID: 35793229

RUNX2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of RUNX2
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of RUNX2

Upstream Pathway Annotation of RUNX2
T(co)F Pathway Name Source Gene Number
RUNX2
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Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082
WikiPathways 6
RUNX2
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Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101
WikiPathways 8
RUNX2
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Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525
WikiPathways 9
RUNX2
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YAP1- and WWTR1 (TAZ)-stimulated gene expression
Reactome 29
RUNX2
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Hs_Endochondral_Ossification_WP474_87977
WikiPathways 43
RUNX2
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Notch-mediated HES/HEY network
PID 48
RUNX2
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FGF signaling pathway
PID 55
RUNX2
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Hs_MAPK_Signaling_Pathway_WP382_79951
WikiPathways 58
RUNX2
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Regulation of retinoblastoma protein
PID 67
RUNX2
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Regulation of nuclear SMAD2/3 signaling
PID 82
RUNX2
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Leptin
NetPath 98
RUNX2
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AndrogenReceptor
NetPath 167
RUNX2
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TGF_beta_Receptor
NetPath 220
Target Gene Expression Analysis
Expression Atlas of RUNX2