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T(co)F Overview
T(co)F: TP53
Species: Homo sapiens
Knock-Method: knockout
T(co)F Class: p53 domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: MOLP8
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 4
Data Source: GEO
Profile ID: GSE73665
Platform: GPL10558
Pubmed ID: -

TP53- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of TP53
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of TP53

Upstream Pathway Annotation of TP53
T(co)F Pathway Name Source Gene Number
TP53
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Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639
WikiPathways 5
TP53
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P53 pathway feedback loops 1
PANTHER 6
TP53
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PLK3 signaling events
PID 6
TP53
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Activation of PUMA and translocation to mitochondria
Reactome 8
TP53
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Hs_Steroid_Biosynthesis_WP496_69016
WikiPathways 8
TP53
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Hs_G1_to_S_cell_cycle_control_WP45_80001
WikiPathways 8
TP53
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Stabilization of p53
Reactome 9
TP53
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Hs_LncRNA-mediated_mechanisms_of_therapeutic_resistance_WP3672_87395
WikiPathways 9
TP53
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Hs_TP53_Network_WP1742_71700
WikiPathways 10
TP53
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Hs_Nuclear_Receptors_in_Lipid_Metabolism_and_Toxicity_WP299_89331
WikiPathways 10
TP53
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Vincristine Action Pathway
SMPDB 10
TP53
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Vindesine Action Pathway
SMPDB 10
TP53
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Vinblastine Action Pathway
SMPDB 11
TP53
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Vinorelbine Action Pathway
SMPDB 11
TP53
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TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome 12
TP53
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TP53 Regulates Transcription of Death Receptors and Ligands
Reactome 12
TP53
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TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Reactome 13
TP53
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Regulation of TP53 Activity through Association with Co-factors
Reactome 14
TP53
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SUMOylation of transcription factors
Reactome 14
TP53
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TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Reactome 14
TP53
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Hs_Copper_homeostasis_WP3286_89205
WikiPathways 15
TP53
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Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520
WikiPathways 16
TP53
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Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Reactome 17
TP53
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Hs_Bladder_Cancer_WP2828_89143
WikiPathways 17
TP53
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TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome 18
TP53
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Regulation of TP53 Activity through Methylation
Reactome 19
TP53
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TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome 19
TP53
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Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
PID 19
TP53
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TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Reactome 21
TP53
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p53 pathway by glucose deprivation
PANTHER 21
TP53
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Regulation of TP53 Activity through Acetylation
Reactome 23
TP53
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Hs_Alzheimers_Disease_WP2059_87372
WikiPathways 24
TP53
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Thyroid cancer
KEGG 25
TP53
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Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271
WikiPathways 27
TP53
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Hs_DNA_Damage_Response_WP707_82937
WikiPathways 28
TP53
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Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694
WikiPathways 28
TP53
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Hs_Gastric_Cancer_Network_2_WP2363_87523
WikiPathways 28
TP53
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Pre-NOTCH Transcription and Translation
Reactome 29
TP53
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BARD1 signaling events
PID 29
TP53
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Oncogene Induced Senescence
Reactome 30
TP53
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Hs_ATM_Signaling_Pathway_WP2516_90247
WikiPathways 32
TP53
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Hs_Cell_Cycle_WP179_89516
WikiPathways 33
TP53
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Hs_Integrated_Cancer_Pathway_WP1971_82939
WikiPathways 33
TP53
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Aurora A signaling
PID 33
TP53
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Regulation of TP53 Degradation
Reactome 35
TP53
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Signaling mediated by p38-alpha and p38-beta
PID 35
TP53
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Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974
WikiPathways 36
TP53
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Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640
WikiPathways 36
TP53
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Hs_ErbB_Signaling_Pathway_WP673_91869
WikiPathways 37
TP53
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Bladder cancer
KEGG 38
TP53
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Association of TriC/CCT with target proteins during biosynthesis
Reactome 39
TP53
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p53 pathway
PANTHER 39
TP53
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Signaling events mediated by HDAC Class III
PID 41
TP53
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p53 pathway feedback loops 2
PANTHER 42
TP53
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LKB1 signaling events
PID 43
TP53
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Hs_Tryptophan_metabolism_WP465_85055
WikiPathways 45
TP53
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G2/M Checkpoints
Reactome 50
TP53
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Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367
WikiPathways 50
TP53
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Basal cell carcinoma
KEGG 51
TP53
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Autodegradation of the E3 ubiquitin ligase COP1
Reactome 51
TP53
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Endometrial cancer
KEGG 52
TP53
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Amyotrophic lateral sclerosis (ALS)
KEGG 53
TP53
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Non-small cell lung cancer
KEGG 54
TP53
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
The role of GTSE1 in G2/M progression after G2 checkpoint
Reactome 59
TP53
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p53 pathway
PID 59
TP53
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TP53 Regulates Transcription of DNA Repair Genes
Reactome 61
TP53
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Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193
WikiPathways 62
TP53
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Colorectal cancer
KEGG 63
TP53
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
DNA Damage/Telomere Stress Induced Senescence
Reactome 64
TP53
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Glioma
KEGG 65
TP53
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
p53 signaling pathway
KEGG 66
TP53
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Melanoma
KEGG 69
TP53
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Chronic myeloid leukemia
KEGG 69
TP53
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Pancreatic cancer
KEGG 70
TP53
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Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293
WikiPathways 70
TP53
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AP-1 transcription factor network
PID 71
TP53
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p75(NTR)-mediated signaling
PID 74
TP53
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome 75
TP53
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Validated targets of C-MYC transcriptional activation
PID 80
TP53
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Small cell lung cancer
KEGG 83
TP53
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G2/M DNA damage checkpoint
Reactome 84
TP53
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Prostate cancer
KEGG 85
TP53
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TP53 Regulates Metabolic Genes
Reactome 85
TP53
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Glucocorticoid receptor regulatory network
PID 85
TP53
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Apoptosis
KEGG 88
TP53
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Regulation of TP53 Activity through Phosphorylation
Reactome 89
TP53
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Apoptosis signaling pathway
PANTHER 104
TP53
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Factors involved in megakaryocyte development and platelet production
Reactome 111
TP53
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Huntington disease
PANTHER 113
TP53
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Oxidative Stress Induced Senescence
Reactome 120
TP53
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
TP53
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Cell cycle
KEGG 124
TP53
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Neurotrophin signaling pathway
KEGG 126
TP53
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Hepatitis C
KEGG 134
TP53
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Wnt signaling pathway
KEGG 135
TP53
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Direct p53 effectors
PID 141
TP53
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Huntington's disease
KEGG 182
TP53
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TGF_beta_Receptor
NetPath 220
TP53
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MAPK signaling pathway
KEGG 264
TP53
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TNFalpha
NetPath 274
TP53
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Pathways in cancer
KEGG 321
TP53
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of TP53