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T(co)F Overview
T(co)F: SP1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: C2H2 zinc finger factors
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: MDA-MB-231
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 6
# of Treat: 3
Data Source: GEO
Profile ID: GSE48979
Platform: GPL6947
Pubmed ID: -

SP1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of SP1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of SP1

Upstream Pathway Annotation of SP1
T(co)F Pathway Name Source Gene Number
SP1
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Hs_Estrogen_signaling_pathway_WP712_78491
WikiPathways 13
SP1
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Hs_Interleukin-11_Signaling_Pathway_WP2332_79525
WikiPathways 17
SP1
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Hs_AGE-RAGE_pathway_WP2324_89798
WikiPathways 27
SP1
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Hs_Androgen_receptor_signaling_pathway_WP138_79958
WikiPathways 27
SP1
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Oncogene Induced Senescence
Reactome 30
SP1
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IL2 signaling events mediated by STAT5
PID 30
SP1
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome 32
SP1
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Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078
WikiPathways 33
SP1
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HIF-2-alpha transcription factor network
PID 34
SP1
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Hs_Leptin_signaling_pathway_WP2034_89856
WikiPathways 37
SP1
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
PID 37
SP1
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Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017
WikiPathways 41
SP1
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Activation of gene expression by SREBF (SREBP)
Reactome 42
SP1
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FOXM1 transcription factor network
PID 43
SP1
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FOXA1 transcription factor network
PID 45
SP1
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FOXA2 and FOXA3 transcription factor networks
PID 45
SP1
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Validated transcriptional targets of TAp63 isoforms
PID 54
SP1
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Validated targets of C-MYC transcriptional repression
PID 63
SP1
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IL4-mediated signaling events
PID 66
SP1
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Hs_TGF-beta_Signaling_Pathway_WP366_90028
WikiPathways 67
SP1
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HIF-1-alpha transcription factor network
PID 67
SP1
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RNA polymerase II transcribes snRNA genes
Reactome 70
SP1
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Regulation of Telomerase
PID 70
SP1
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AP-1 transcription factor network
PID 71
SP1
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E2F transcription factor network
PID 77
SP1
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p73 transcription factor network
PID 80
SP1
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TGF-beta signaling pathway
KEGG 82
SP1
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Regulation of nuclear SMAD2/3 signaling
PID 82
SP1
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C-MYB transcription factor network
PID 87
SP1
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Leptin
NetPath 98
SP1
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Hs_EGF-EGFR_Signaling_Pathway_WP437_79266
WikiPathways 107
SP1
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PPARA activates gene expression
Reactome 113
SP1
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Huntington disease
PANTHER 113
SP1
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
SP1
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Direct p53 effectors
PID 141
SP1
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AndrogenReceptor
NetPath 167
SP1
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Huntington's disease
KEGG 182
SP1
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TGF_beta_Receptor
NetPath 220
SP1
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of SP1