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T(co)F Overview
T(co)F: RELA
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Rel homology region (RHR) factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 3
# of Treat: 1
Data Source: GEO
Profile ID: GSE31912
Platform: GPL570
Pubmed ID: 22536322

RELA- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of RELA
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of RELA

Upstream Pathway Annotation of RELA
T(co)F Pathway Name Source Gene Number
RELA
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CLEC7A/inflammasome pathway
Reactome 6
RELA
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IkBA variant leads to EDA-ID
Reactome 7
RELA
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Interleukin-1 processing
Reactome 7
RELA
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IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
Reactome 8
RELA
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IKK-NF-kappaB cascade ( B cell receptor signaling )
INOH 8
RELA
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IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) )
INOH 8
RELA
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IKK-NF-kappaB cascade ( CD4 T cell receptor signaling )
INOH 8
RELA
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Regulated proteolysis of p75NTR
Reactome 10
RELA
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IKK-NFkB cascade ( TNFR1 signaling pathway )
INOH 11
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
NF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) )
INOH 12
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Reactome 13
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
NF-kB is activated and signals survival
Reactome 13
RELA
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Atypical NF-kappaB pathway
PID 14
RELA
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Hs_Interleukin-11_Signaling_Pathway_WP2332_79525
WikiPathways 17
RELA
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Hs_IL17_signaling_pathway_WP2112_89838
WikiPathways 20
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
CD209 (DC-SIGN) signaling
Reactome 21
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
RIP-mediated NFkB activation via ZBP1
Reactome 21
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
TRAF6 mediated NF-kB activation
Reactome 24
RELA
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TSLP
NetPath 24
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Canonical NF-kappaB pathway
PID 24
RELA
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Reactome 26
RELA
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Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016
WikiPathways 26
RELA
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Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910
WikiPathways 27
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_AGE-RAGE_pathway_WP2324_89798
WikiPathways 27
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_p38_MAPK_Signaling_Pathway_WP400_72084
WikiPathways 28
RELA
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T cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) ( CD4 T cell receptor signaling (NF-kB cascade) )
INOH 30
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Osteopontin-mediated events
PID 32
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
HIV-1 Nef: Negative effector of Fas and TNF-alpha
PID 33
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
T cell receptor signaling pathway ( CD4 T cell receptor signaling )
INOH 33
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-1_signaling_pathway_WP195_89932
WikiPathways 34
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL1-mediated signaling events
PID 34
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
TWEAK
NetPath 35
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
CD40/CD40L signaling
PID 36
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035
WikiPathways 37
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL23-mediated signaling events
PID 37
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL2 signaling events mediated by PI3K
PID 38
RELA
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Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017
WikiPathways 41
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
FSH
NetPath 44
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668
WikiPathways 44
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
TNF receptor signaling pathway
PID 46
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Ceramide signaling pathway
PID 49
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Angiopoietin receptor Tie2-mediated signaling
PID 50
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Prolactin_Signaling_Pathway_WP2037_90015
WikiPathways 52
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Acute myeloid leukemia
KEGG 53
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Cytosolic DNA-sensing pathway
KEGG 56
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
NOD-like receptor signaling pathway
KEGG 60
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Shigellosis
KEGG 60
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Dectin-1 mediated noncanonical NF-kB signaling
Reactome 61
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL12-mediated signaling events
PID 62
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Fc-epsilon receptor I signaling in mast cells
PID 64
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Adipocytokine signaling pathway
KEGG 65
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
LPA receptor mediated events
PID 65
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Activation of NF-kappaB in B cells
Reactome 66
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Epithelial cell signaling in Helicobacter pylori infection
KEGG 67
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Chronic myeloid leukemia
KEGG 69
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL1
NetPath 69
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
B cell receptor signaling pathway
KEGG 70
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Pancreatic cancer
KEGG 70
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
BCR signaling pathway
PID 70
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
RIG-I-like receptor signaling pathway
KEGG 71
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Leishmaniasis
KEGG 71
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL4
NetPath 75
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Notch
NetPath 76
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
CLEC7A (Dectin-1) signaling
Reactome 78
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Transcriptional regulation of white adipocyte differentiation
Reactome 79
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803
WikiPathways 80
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
p73 transcription factor network
PID 80
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL2
NetPath 81
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
TSH
NetPath 82
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Small cell lung cancer
KEGG 83
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
RANKL
NetPath 84
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Prostate cancer
KEGG 85
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Glucocorticoid receptor regulatory network
PID 85
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Apoptosis
KEGG 88
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
FCERI mediated NF-kB activation
Reactome 88
RELA
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling events mediated by HDAC Class I
PID 89
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Leptin
NetPath 98
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Toll-like receptor signaling pathway
KEGG 100
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Downstream TCR signaling
Reactome 101
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Chagas disease
KEGG 103
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Amoebiasis
KEGG 103
RELA
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
KitReceptor
NetPath 104
RELA
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Apoptosis signaling pathway
PANTHER 104
RELA
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T cell receptor signaling pathway
KEGG 105
RELA
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Prolactin
NetPath 105
RELA
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Senescence-Associated Secretory Phenotype (SASP)
Reactome 108
RELA
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Neurotrophin signaling pathway
KEGG 126
RELA
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Toxoplasmosis
KEGG 131
RELA
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Hepatitis C
KEGG 134
RELA
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Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
WikiPathways 153
RELA
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BCR
NetPath 161
RELA
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Chemokine signaling pathway
KEGG 187
RELA
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Inflammation mediated by chemokine and cytokine signaling pathway
PANTHER 189
RELA
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TCR
NetPath 261
RELA
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MAPK signaling pathway
KEGG 264
RELA
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TNFalpha
NetPath 274
RELA
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Pathways in cancer
KEGG 321
RELA
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of RELA