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T(co)F Overview
T(co)F: HIF1A
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic helix-loop-helix factors (bHLH)
T(co)F Superclass: Basic domains
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 3
# of Treat: 1
Data Source: GEO
Profile ID: GSE31912
Platform: GPL570
Pubmed ID: 22536322

HIF1A- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HIF1A
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HIF1A

Upstream Pathway Annotation of HIF1A
T(co)F Pathway Name Source Gene Number
HIF1A
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PTK6 Expression
Reactome 5
HIF1A
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PTK6 promotes HIF1A stabilization
Reactome 6
HIF1A
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Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101
WikiPathways 8
HIF1A
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Regulation of gene expression by Hypoxia-inducible Factor
Reactome 10
HIF1A
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Hs_Notch_Signaling_Pathway_WP61_78592
WikiPathways 16
HIF1A
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Hypoxia response via HIF activation
PANTHER 16
HIF1A
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Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Reactome 18
HIF1A
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Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
PID 19
HIF1A
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Hs_AGE-RAGE_pathway_WP2324_89798
WikiPathways 27
HIF1A
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VEGFR1 specific signals
PID 29
HIF1A
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Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640
WikiPathways 36
HIF1A
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BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome 42
HIF1A
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NOTCH1 Intracellular Domain Regulates Transcription
Reactome 47
HIF1A
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Notch-mediated HES/HEY network
PID 48
HIF1A
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Circadian Clock
Reactome 49
HIF1A
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mTOR signaling pathway
KEGG 50
HIF1A
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VEGF signaling pathway
PANTHER 54
HIF1A
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Renal cell carcinoma
KEGG 65
HIF1A
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HIF-1-alpha transcription factor network
PID 67
HIF1A
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AP-1 transcription factor network
PID 71
HIF1A
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Parkinson disease
PANTHER 85
HIF1A
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Angiogenesis
PANTHER 141
HIF1A
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Pathways in cancer
KEGG 321
Target Gene Expression Analysis
Expression Atlas of HIF1A