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T(co)F Overview
T(co)F: STAT6
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: STAT domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR024HAR
Platform: -
Pubmed ID: 22955616

STAT6- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of STAT6
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of STAT6

Upstream Pathway Annotation of STAT6
T(co)F Pathway Name Source Gene Number
STAT6
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IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) )
INOH 7
STAT6
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Hs_G1_to_S_cell_cycle_control_WP45_80001
WikiPathways 8
STAT6
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Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )
INOH 8
STAT6
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Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )
INOH 8
STAT6
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IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) )
INOH 10
STAT6
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Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )
INOH 14
STAT6
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JAK/STAT signaling pathway
PANTHER 15
STAT6
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Hs_Cytokines_and_Inflammatory_Response_WP530_79331
WikiPathways 21
STAT6
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IL9
NetPath 24
STAT6
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TSLP
NetPath 24
STAT6
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Hs_TGF-beta_Receptor_Signaling_WP560_90187
WikiPathways 28
STAT6
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Downstream signal transduction
Reactome 29
STAT6
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Signaling events mediated by TCPTP
PID 40
STAT6
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Hs_IL-4_Signaling_Pathway_WP395_89828
WikiPathways 41
STAT6
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Hs_Tryptophan_metabolism_WP465_85055
WikiPathways 45
STAT6
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IL12-mediated signaling events
PID 62
STAT6
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IL4-mediated signaling events
PID 66
STAT6
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IL4
NetPath 75
STAT6
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Interleukin signaling pathway
PANTHER 86
STAT6
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JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram )
INOH 97
STAT6
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EGF receptor signaling pathway
PANTHER 109
STAT6
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PDGF signaling pathway
PANTHER 113
STAT6
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Jak-STAT signaling pathway
KEGG 149
STAT6
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Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
INOH 178
Target Gene Expression Analysis
Expression Atlas of STAT6