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T(co)F Overview
T(co)F: HDAC8
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TcoF
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR369BHC
Platform: -
Pubmed ID: 22955616

HDAC8- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HDAC8
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HDAC8

Upstream Pathway Annotation of HDAC8
T(co)F Pathway Name Source Gene Number
HDAC8
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Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) )
INOH 21
HDAC8
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NOTCH1 Intracellular Domain Regulates Transcription
Reactome 47
HDAC8
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome 57
HDAC8
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome 57
HDAC8
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Signaling events mediated by HDAC Class I
PID 89
HDAC8
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HDACs deacetylate histones
Reactome 94
HDAC8
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Resolution of Sister Chromatid Cohesion
Reactome 100
HDAC8
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Separation of Sister Chromatids
Reactome 163
HDAC8
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Wnt signaling pathway
PANTHER 250
Target Gene Expression Analysis
Expression Atlas of HDAC8