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T(co)F Overview
T(co)F: NFATC1
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: Rel homology region (RHR) factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR381TNV
Platform: -
Pubmed ID: 22955616

NFATC1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of NFATC1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of NFATC1

Upstream Pathway Annotation of NFATC1
T(co)F Pathway Name Source Gene Number
NFATC1
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Hs_TLR4_Signaling_and_Tolerance_WP3851_90114
WikiPathways 8
NFATC1
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Signaling by Wnt
Reactome 10
NFATC1
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CLEC7A (Dectin-1) induces NFAT activation
Reactome 13
NFATC1
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Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016
WikiPathways 26
NFATC1
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Calcium signaling in the CD4+ TCR pathway
PID 29
NFATC1
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
PID 37
NFATC1
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FCERI mediated Ca+2 mobilization
Reactome 41
NFATC1
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
PID 50
NFATC1
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
PID 54
NFATC1
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Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937
WikiPathways 60
NFATC1
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Ca2+ pathway
Reactome 62
NFATC1
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Downstream signaling in nave CD8+ T cells
PID 69
NFATC1
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VEGF signaling pathway
KEGG 70
NFATC1
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B cell receptor signaling pathway
KEGG 70
NFATC1
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BCR signaling pathway
PID 70
NFATC1
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AP-1 transcription factor network
PID 71
NFATC1
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RANKL
NetPath 84
NFATC1
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Glucocorticoid receptor regulatory network
PID 85
NFATC1
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T cell receptor signaling pathway
KEGG 105
NFATC1
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Natural killer cell mediated cytotoxicity
KEGG 125
NFATC1
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Axon guidance
KEGG 126
NFATC1
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Wnt signaling pathway
KEGG 135
NFATC1
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Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
WikiPathways 153
NFATC1
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Inflammation mediated by chemokine and cytokine signaling pathway
PANTHER 189
NFATC1
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Wnt signaling pathway
PANTHER 250
NFATC1
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TCR
NetPath 261
Target Gene Expression Analysis
Expression Atlas of NFATC1