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T(co)F Overview
T(co)F: TP63
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: p53 domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: HaCaT
Tissue Type: Immortalized_keratinocyte
Biosample Type: Cell line
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE88832
Platform: GPL6244
Pubmed ID: 28041841

TP63- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of TP63
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of TP63

Upstream Pathway Annotation of TP63
T(co)F Pathway Name Source Gene Number
TP63
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Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473
WikiPathways 5
TP63
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P53 pathway feedback loops 1
PANTHER 6
TP63
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Activation of PUMA and translocation to mitochondria
Reactome 8
TP63
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Hs_Urea_cycle_and_metabolism_of_amino_groups_WP497_72142
WikiPathways 8
TP63
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TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome 12
TP63
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TP53 Regulates Transcription of Death Receptors and Ligands
Reactome 12
TP63
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Regulation of TP53 Activity through Association with Co-factors
Reactome 14
TP63
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TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Reactome 14
TP63
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TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome 19
TP63
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p53 pathway by glucose deprivation
PANTHER 21
TP63
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Hs_Focal_Adhesion_WP306_80308
WikiPathways 26
TP63
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Hs_TGF-beta_Receptor_Signaling_WP560_90187
WikiPathways 28
TP63
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p53 pathway
PANTHER 39
TP63
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p53 pathway feedback loops 2
PANTHER 42
TP63
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Validated transcriptional targets of deltaNp63 isoforms
PID 47
TP63
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Validated transcriptional targets of TAp63 isoforms
PID 54
TP63
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p73 transcription factor network
PID 80
TP63
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TP53 Regulates Metabolic Genes
Reactome 85
TP63
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Huntington disease
PANTHER 113
TP63
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Direct p53 effectors
PID 141
Target Gene Expression Analysis
Expression Atlas of TP63