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T(co)F Overview
T(co)F: PTEN
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TcoF
Biosample Name: SKBR3
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE7562
Platform: GPL570
Pubmed ID: 17560336

PTEN- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of PTEN
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of PTEN

Upstream Pathway Annotation of PTEN
T(co)F Pathway Name Source Gene Number
PTEN
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Negative regulation of the PI3K/AKT network
Reactome 8
PTEN
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D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HumanCyc 15
PTEN
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AKT(PKB)-mTOR signaling ( Insulin receptor signaling (Mammal) )
INOH 15
PTEN
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AKT(PKB)-TOR signaling ( Insulin receptor signaling (D. melanogaster) )
INOH 15
PTEN
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Hypoxia response via HIF activation
PANTHER 16
PTEN
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3-phosphoinositide degradation
HumanCyc 20
PTEN
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superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
HumanCyc 20
PTEN
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Joubert syndrome
SMPDB 21
PTEN
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Phosphatidylinositol Phosphate Metabolism
SMPDB 21
PTEN
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Insulin/IGF pathway-protein kinase B signaling cascade
PANTHER 22
PTEN
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Synthesis of IP3 and IP4 in the cytosol
Reactome 27
PTEN
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Hs_Integrated_Cancer_Pathway_WP1971_82939
WikiPathways 33
PTEN
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Synthesis of PIPs at the plasma membrane
Reactome 34
PTEN
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PI3 kinase pathway
PANTHER 38
PTEN
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p53 pathway
PANTHER 39
PTEN
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Hs_Neural_Crest_Differentiation_WP2064_79263
WikiPathways 40
PTEN
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p53 pathway feedback loops 2
PANTHER 42
PTEN
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Inositol phosphate metabolism ( Inositol phosphate metabolism )
INOH 42
PTEN
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Class I PI3K signaling events
PID 46
PTEN
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RhoA signaling pathway
PID 46
PTEN
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Endometrial cancer
KEGG 52
PTEN
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Signaling events mediated by Stem cell factor receptor (c-Kit)
PID 53
PTEN
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Inositol phosphate metabolism
KEGG 54
PTEN
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Glioma
KEGG 65
PTEN
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p53 signaling pathway
KEGG 66
PTEN
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superpathway of inositol phosphate compounds
HumanCyc 68
PTEN
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Melanoma
KEGG 69
PTEN
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TCR signaling in nave CD4+ T cells
PID 69
PTEN
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BCR signaling pathway
PID 70
PTEN
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AP-1 transcription factor network
PID 71
PTEN
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Phosphatidylinositol signaling system
KEGG 78
PTEN
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PIP3 activates AKT signaling
Reactome 81
PTEN
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Small cell lung cancer
KEGG 83
PTEN
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Prostate cancer
KEGG 85
PTEN
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TP53 Regulates Metabolic Genes
Reactome 85
PTEN
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Leptin
NetPath 98
PTEN
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Downstream TCR signaling
Reactome 101
PTEN
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
PTEN
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PDGFR-beta signaling pathway
PID 125
PTEN
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Tight junction
KEGG 131
PTEN
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Direct p53 effectors
PID 141
PTEN
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AndrogenReceptor
NetPath 167
PTEN
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Inflammation mediated by chemokine and cytokine signaling pathway
PANTHER 189
PTEN
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Focal adhesion
KEGG 197
PTEN
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Pathways in cancer
KEGG 321
PTEN
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of PTEN