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T(co)F Overview
T(co)F: IRF7
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: Primary human bronchial epithelial cells
Tissue Type: Bronchus
Biosample Type: Primary cell
# of Control: 10
# of Treat: 10
Data Source: GEO
Profile ID: GSE70190
Platform: GPL20609
Pubmed ID: 26810609

IRF7- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of IRF7
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of IRF7

Upstream Pathway Annotation of IRF7
T(co)F Pathway Name Source Gene Number
IRF7
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Hs_TLR4_Signaling_and_Tolerance_WP3851_90114
WikiPathways 8
IRF7
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TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Reactome 11
IRF7
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DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Reactome 13
IRF7
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TRAF3-dependent IRF activation pathway
Reactome 14
IRF7
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Hs_Toll-like_Receptor_Signaling_Pathway_WP75_83867
WikiPathways 17
IRF7
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Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome 18
IRF7
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TRAF6 mediated IRF7 activation
Reactome 33
IRF7
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Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707
WikiPathways 34
IRF7
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Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172
WikiPathways 47
IRF7
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Cytosolic DNA-sensing pathway
KEGG 56
IRF7
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Interferon alpha/beta signaling
Reactome 67
IRF7
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RIG-I-like receptor signaling pathway
KEGG 71
IRF7
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Regulation of nuclear SMAD2/3 signaling
PID 82
IRF7
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Interferon gamma signaling
Reactome 88
IRF7
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Toll-like receptor signaling pathway
KEGG 100
IRF7
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Factors involved in megakaryocyte development and platelet production
Reactome 111
IRF7
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Hepatitis C
KEGG 134
Target Gene Expression Analysis
Expression Atlas of IRF7