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T(co)F Overview
T(co)F: FOXO1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Fork head / winged helix factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: HUVEC
Tissue Type: Umbilical_vein
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE67390
Platform: GPL10558
Pubmed ID: 28904225

FOXO1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of FOXO1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of FOXO1

Upstream Pathway Annotation of FOXO1
T(co)F Pathway Name Source Gene Number
FOXO1
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Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) )
INOH 7
FOXO1
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Negative regulation of gene expression ( Insulin receptor signaling (Mammal) )
INOH 7
FOXO1
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Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178
WikiPathways 8
FOXO1
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AKT phosphorylates targets in the nucleus
Reactome 9
FOXO1
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Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629
WikiPathways 9
FOXO1
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Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581
WikiPathways 9
FOXO1
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Hs_Energy_Metabolism_WP1541_91584
WikiPathways 13
FOXO1
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Regulation of gene expression in beta cells
Reactome 17
FOXO1
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Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080
WikiPathways 20
FOXO1
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Insulin/IGF pathway-protein kinase B signaling cascade
PANTHER 22
FOXO1
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Constitutive Signaling by AKT1 E17K in Cancer
Reactome 25
FOXO1
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Hs_AGE-RAGE_pathway_WP2324_89798
WikiPathways 27
FOXO1
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IL-7
NetPath 28
FOXO1
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Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628
WikiPathways 32
FOXO1
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Class I PI3K signaling events mediated by Akt
PID 35
FOXO1
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Hs_ErbB_Signaling_Pathway_WP673_91869
WikiPathways 37
FOXO1
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PI3 kinase pathway
PANTHER 38
FOXO1
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Signaling events mediated by HDAC Class III
PID 41
FOXO1
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FSH
NetPath 44
FOXO1
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IL6-mediated signaling events
PID 48
FOXO1
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Angiopoietin receptor Tie2-mediated signaling
PID 50
FOXO1
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FoxO family signaling
PID 50
FOXO1
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Regulation of Androgen receptor activity
PID 54
FOXO1
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Regulation of nuclear SMAD2/3 signaling
PID 82
FOXO1
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IL3
NetPath 84
FOXO1
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Prostate cancer
KEGG 85
FOXO1
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IL6
NetPath 85
FOXO1
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CXCR4-mediated signaling events
PID 87
FOXO1
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MAPK6/MAPK4 signaling
Reactome 90
FOXO1
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Leptin
NetPath 98
FOXO1
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
FOXO1
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Insulin signaling pathway
KEGG 134
FOXO1
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Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
WikiPathways 153
FOXO1
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BCR
NetPath 161
FOXO1
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AndrogenReceptor
NetPath 167
FOXO1
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TGF_beta_Receptor
NetPath 220
FOXO1
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TNFalpha
NetPath 274
FOXO1
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Pathways in cancer
KEGG 321
FOXO1
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of FOXO1