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T(co)F Overview
T(co)F: FOXO3
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Fork head / winged helix factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: PANC1
Tissue Type: Pancreas
Biosample Type: Cell line
# of Control: 1
# of Treat: 1
Data Source: GEO
Profile ID: GSE66404
Platform: GPL17077
Pubmed ID: -

FOXO3- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of FOXO3
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of FOXO3

Upstream Pathway Annotation of FOXO3
T(co)F Pathway Name Source Gene Number
FOXO3
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Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) )
INOH 7
FOXO3
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Negative regulation of gene expression ( Insulin receptor signaling (Mammal) )
INOH 7
FOXO3
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Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178
WikiPathways 8
FOXO3
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AKT phosphorylates targets in the nucleus
Reactome 9
FOXO3
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Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384
WikiPathways 11
FOXO3
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Hs_Energy_Metabolism_WP1541_91584
WikiPathways 13
FOXO3
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Hs_Estrogen_signaling_pathway_WP712_78491
WikiPathways 13
FOXO3
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Signaling by NODAL
Reactome 19
FOXO3
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Insulin/IGF pathway-protein kinase B signaling cascade
PANTHER 22
FOXO3
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Constitutive Signaling by AKT1 E17K in Cancer
Reactome 25
FOXO3
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Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271
WikiPathways 27
FOXO3
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IL-7
NetPath 28
FOXO3
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Hs_IL-2_Signaling_Pathway_WP49_91243
WikiPathways 33
FOXO3
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Class I PI3K signaling events mediated by Akt
PID 35
FOXO3
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Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974
WikiPathways 36
FOXO3
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Trk receptor signaling mediated by PI3K and PLC-gamma
PID 36
FOXO3
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PI3 kinase pathway
PANTHER 38
FOXO3
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IL2 signaling events mediated by PI3K
PID 38
FOXO3
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Signaling events mediated by HDAC Class III
PID 41
FOXO3
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Hs_Endochondral_Ossification_WP474_87977
WikiPathways 43
FOXO3
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FSH
NetPath 44
FOXO3
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Class I PI3K signaling events
PID 46
FOXO3
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Insulin Pathway
PID 47
FOXO3
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FoxO family signaling
PID 50
FOXO3
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Endometrial cancer
KEGG 52
FOXO3
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Signaling events mediated by Stem cell factor receptor (c-Kit)
PID 53
FOXO3
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Non-small cell lung cancer
KEGG 54
FOXO3
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IL5
NetPath 59
FOXO3
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Validated targets of C-MYC transcriptional repression
PID 63
FOXO3
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Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803
WikiPathways 80
FOXO3
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p73 transcription factor network
PID 80
FOXO3
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IL2
NetPath 81
FOXO3
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Regulation of nuclear SMAD2/3 signaling
PID 82
FOXO3
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IL3
NetPath 84
FOXO3
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IL6
NetPath 85
FOXO3
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Interleukin signaling pathway
PANTHER 86
FOXO3
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MAPK6/MAPK4 signaling
Reactome 90
FOXO3
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KitReceptor
NetPath 104
FOXO3
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Prolactin
NetPath 105
FOXO3
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Neurotrophin signaling pathway
KEGG 126
FOXO3
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Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
WikiPathways 153
FOXO3
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BCR
NetPath 161
FOXO3
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Chemokine signaling pathway
KEGG 187
FOXO3
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TGF_beta_Receptor
NetPath 220
Target Gene Expression Analysis
Expression Atlas of FOXO3