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T(co)F Overview
T(co)F: HES1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Basic helix-loop-helix factors (bHLH)
T(co)F Superclass: Basic domains
Biosample Name: CUTLL1
Tissue Type: Haematopoietic_and_lymphoid_tissue_Blood
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE65872
Platform: GPL10558
Pubmed ID: 25784680

HES1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HES1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HES1

Upstream Pathway Annotation of HES1
T(co)F Pathway Name Source Gene Number
HES1
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Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Reactome 7
HES1
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NOTCH2 intracellular domain regulates transcription
Reactome 12
HES1
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Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527
WikiPathways 12
HES1
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Maturity onset diabetes of the young
KEGG 25
HES1
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ID
NetPath 38
HES1
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Notch signaling pathway
KEGG 44
HES1
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NOTCH1 Intracellular Domain Regulates Transcription
Reactome 47
HES1
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Validated transcriptional targets of deltaNp63 isoforms
PID 47
HES1
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Fanconi anemia pathway
PID 48
HES1
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Notch-mediated HES/HEY network
PID 48
HES1
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome 57
HES1
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome 57
HES1
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ATF-2 transcription factor network
PID 59
HES1
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Notch
NetPath 76
HES1
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C-MYB transcription factor network
PID 87
Target Gene Expression Analysis
Expression Atlas of HES1