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T(co)F Overview
T(co)F: NFKB2
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Rel homology region (RHR) factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: L-1236
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 6
# of Treat: 6
Data Source: GEO
Profile ID: GSE64234
Platform: GPL6244
Pubmed ID: 26988706

NFKB2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of NFKB2
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of NFKB2

Upstream Pathway Annotation of NFKB2
T(co)F Pathway Name Source Gene Number
NFKB2
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Alternative NF-kappaB pathway
PID 6
NFKB2
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IkBA variant leads to EDA-ID
Reactome 7
NFKB2
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Interleukin-1 processing
Reactome 7
NFKB2
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IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
Reactome 8
NFKB2
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DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Reactome 13
NFKB2
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RIP-mediated NFkB activation via ZBP1
Reactome 21
NFKB2
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TRAF6 mediated NF-kB activation
Reactome 24
NFKB2
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TSLP
NetPath 24
NFKB2
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Reactome 26
NFKB2
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TWEAK
NetPath 35
NFKB2
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMPDB 37
NFKB2
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMPDB 38
NFKB2
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NIK-->noncanonical NF-kB signaling
Reactome 58
NFKB2
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Dectin-1 mediated noncanonical NF-kB signaling
Reactome 61
NFKB2
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Hs_TNF_alpha_Signaling_Pathway_WP231_89895
WikiPathways 61
NFKB2
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IL12-mediated signaling events
PID 62
NFKB2
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RANKL
NetPath 84
NFKB2
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Apoptosis signaling pathway
PANTHER 104
NFKB2
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Inflammation mediated by chemokine and cytokine signaling pathway
PANTHER 189
NFKB2
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MAPK signaling pathway
KEGG 264
NFKB2
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TNFalpha
NetPath 274
NFKB2
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Pathways in cancer
KEGG 321
Target Gene Expression Analysis
Expression Atlas of NFKB2