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T(co)F Overview
T(co)F: MYC
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Basic helix-loop-helix factors (bHLH)
T(co)F Superclass: Basic domains
Biosample Name: HT1080
Tissue Type: Soft_tissue
Biosample Type: Cell line
# of Control: 1
# of Treat: 1
Data Source: GEO
Profile ID: GSE60558
Platform: GPL16686
Pubmed ID: 25793315

MYC- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of MYC
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of MYC

Upstream Pathway Annotation of MYC
T(co)F Pathway Name Source Gene Number
MYC
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Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome 7
MYC
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Hs_TP53_Network_WP1742_71700
WikiPathways 10
MYC
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Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384
WikiPathways 11
MYC
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Cyclin E associated events during G1/S transition
Reactome 14
MYC
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Cyclin A:Cdk2-associated events at S phase entry
Reactome 15
MYC
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Hs_IL-7_Signaling_Pathway_WP205_89854
WikiPathways 16
MYC
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Oxidative stress response
PANTHER 23
MYC
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Thyroid cancer
KEGG 25
MYC
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C-MYC pathway
PID 25
MYC
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Hs_Gastric_Cancer_Network_2_WP2363_87523
WikiPathways 28
MYC
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Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697
WikiPathways 30
MYC
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IL2 signaling events mediated by STAT5
PID 30
MYC
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Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113
WikiPathways 31
MYC
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Hs_Apoptosis_WP254_88977
WikiPathways 31
MYC
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome 32
MYC
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Hs_IL-5_Signaling_Pathway_WP127_78498
WikiPathways 35
MYC
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Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974
WikiPathways 36
MYC
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Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640
WikiPathways 36
MYC
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CD40/CD40L signaling
PID 36
MYC
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Bladder cancer
KEGG 38
MYC
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IL2 signaling events mediated by PI3K
PID 38
MYC
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Hs_Neural_Crest_Differentiation_WP2064_79263
WikiPathways 40
MYC
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p53 pathway feedback loops 2
PANTHER 42
MYC
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FOXM1 transcription factor network
PID 43
MYC
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LKB1 signaling events
PID 43
MYC
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Presenilin action in Notch and Wnt signaling
PID 46
MYC
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NOTCH1 Intracellular Domain Regulates Transcription
Reactome 47
MYC
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IL6-mediated signaling events
PID 48
MYC
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Ceramide signaling pathway
PID 49
MYC
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Endometrial cancer
KEGG 52
MYC
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Hs_Prolactin_Signaling_Pathway_WP2037_90015
WikiPathways 52
MYC
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Acute myeloid leukemia
KEGG 53
MYC
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IL2-mediated signaling events
PID 54
MYC
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome 57
MYC
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome 57
MYC
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Notch signaling pathway
PID 58
MYC
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Colorectal cancer
KEGG 63
MYC
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Validated targets of C-MYC transcriptional repression
PID 63
MYC
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Validated nuclear estrogen receptor alpha network
PID 65
MYC
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Chronic myeloid leukemia
KEGG 69
MYC
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Regulation of Telomerase
PID 70
MYC
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AP-1 transcription factor network
PID 71
MYC
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E2F transcription factor network
PID 77
MYC
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p73 transcription factor network
PID 80
MYC
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Regulation of nuclear beta catenin signaling and target gene transcription
PID 80
MYC
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Validated targets of C-MYC transcriptional activation
PID 80
MYC
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TGF-beta signaling pathway
KEGG 82
MYC
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Regulation of nuclear SMAD2/3 signaling
PID 82
MYC
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ErbB signaling pathway
KEGG 83
MYC
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Small cell lung cancer
KEGG 83
MYC
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Interleukin signaling pathway
PANTHER 86
MYC
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C-MYB transcription factor network
PID 87
MYC
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Formation of the beta-catenin:TCF transactivating complex
Reactome 88
MYC
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MAPK6/MAPK4 signaling
Reactome 90
MYC
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Prolactin
NetPath 105
MYC
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Hs_EGF-EGFR_Signaling_Pathway_WP437_79266
WikiPathways 107
MYC
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PDGF signaling pathway
PANTHER 113
MYC
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
MYC
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Cell cycle
KEGG 124
MYC
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PDGFR-beta signaling pathway
PID 125
MYC
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Wnt signaling pathway
KEGG 135
MYC
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Jak-STAT signaling pathway
KEGG 149
MYC
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TGF_beta_Receptor
NetPath 220
MYC
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MAPK signaling pathway
KEGG 264
MYC
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Pathways in cancer
KEGG 321
MYC
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of MYC