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T(co)F Overview
T(co)F: ATM
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Others
T(co)F Superclass: ENCODE_TF
Biosample Name: MCF10A
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 3
# of Treat: 6
Data Source: GEO
Profile ID: GSE54268
Platform: GPL10558
Pubmed ID: 24553445

ATM- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ATM
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ATM

Upstream Pathway Annotation of ATM
T(co)F Pathway Name Source Gene Number
ATM
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Sensing of DNA Double Strand Breaks
Reactome 6
ATM
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PLK3 signaling events
PID 6
ATM
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Stabilization of p53
Reactome 9
ATM
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Hs_TP53_Network_WP1742_71700
WikiPathways 10
ATM
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Hs_ATM_Signaling_Network_in_Development_and_Disease_WP3878_89745
WikiPathways 11
ATM
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TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome 12
ATM
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Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520
WikiPathways 16
ATM
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Regulation of TP53 Activity through Methylation
Reactome 19
ATM
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TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome 19
ATM
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Canonical NF-kappaB pathway
PID 24
ATM
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Homologous DNA Pairing and Strand Exchange
Reactome 25
ATM
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Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Reactome 26
ATM
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Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271
WikiPathways 27
ATM
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Hs_DNA_Damage_Response_WP707_82937
WikiPathways 28
ATM
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Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694
WikiPathways 28
ATM
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BARD1 signaling events
PID 29
ATM
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p38 MAPK signaling pathway
PID 29
ATM
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Hs_ATM_Signaling_Pathway_WP2516_90247
WikiPathways 32
ATM
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Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome 33
ATM
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Hs_Integrated_Cancer_Pathway_WP1971_82939
WikiPathways 33
ATM
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ATM pathway
PID 34
ATM
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Regulation of TP53 Degradation
Reactome 35
ATM
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Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974
WikiPathways 36
ATM
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HDR through Single Strand Annealing (SSA)
Reactome 37
ATM
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Presynaptic phase of homologous DNA pairing and strand exchange
Reactome 39
ATM
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p53 pathway
PANTHER 39
ATM
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p53 pathway feedback loops 2
PANTHER 42
ATM
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HDR through Homologous Recombination (HRR)
Reactome 46
ATM
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Validated transcriptional targets of deltaNp63 isoforms
PID 47
ATM
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Fanconi anemia pathway
PID 48
ATM
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Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367
WikiPathways 50
ATM
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Autodegradation of the E3 ubiquitin ligase COP1
Reactome 51
ATM
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Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Reactome 52
ATM
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p53 pathway
PID 59
ATM
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TP53 Regulates Transcription of DNA Repair Genes
Reactome 61
ATM
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DNA Damage/Telomere Stress Induced Senescence
Reactome 64
ATM
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p53 signaling pathway
KEGG 66
ATM
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Nonhomologous End-Joining (NHEJ)
Reactome 69
ATM
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Regulation of Telomerase
PID 70
ATM
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome 75
ATM
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E2F transcription factor network
PID 77
ATM
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Regulation of HSF1-mediated heat shock response
Reactome 82
ATM
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G2/M DNA damage checkpoint
Reactome 84
ATM
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Meiotic recombination
Reactome 85
ATM
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Apoptosis
KEGG 88
ATM
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Regulation of TP53 Activity through Phosphorylation
Reactome 89
ATM
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Processing of DNA double-strand break ends
Reactome 98
ATM
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
ATM
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Cell cycle
KEGG 124
Target Gene Expression Analysis
Expression Atlas of ATM