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T(co)F Overview
T(co)F: ATF2
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE50165
Platform: GPL6884
Pubmed ID: -

ATF2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ATF2
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ATF2

Upstream Pathway Annotation of ATF2
T(co)F Pathway Name Source Gene Number
ATF2
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p38 cascade ( BMP2 signaling(through TAK1) )
INOH 8
ATF2
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p38 cascade ( TGF-beta signaling(through TAK1) )
INOH 8
ATF2
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Activation of the AP-1 family of transcription factors
Reactome 10
ATF2
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Hs_Energy_Metabolism_WP1541_91584
WikiPathways 13
ATF2
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p38 cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) )
INOH 13
ATF2
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p38 cascade ( Toll-like receptor signaling pathway (p38 cascade) )
INOH 13
ATF2
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p38 cascade ( IL-1 signaling pathway (through p38 cascade) )
INOH 16
ATF2
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Hs_AGE-RAGE_pathway_WP2324_89798
WikiPathways 27
ATF2
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Hs_ATM_Signaling_Pathway_WP2516_90247
WikiPathways 32
ATF2
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Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707
WikiPathways 34
ATF2
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Hs_IL-1_signaling_pathway_WP195_89932
WikiPathways 34
ATF2
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Signaling mediated by p38-alpha and p38-beta
PID 35
ATF2
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMPDB 37
ATF2
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMPDB 38
ATF2
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Hs_IL-4_Signaling_Pathway_WP395_89828
WikiPathways 41
ATF2
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Transcriptional activation of mitochondrial biogenesis
Reactome 43
ATF2
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RhoA signaling pathway
PID 46
ATF2
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Circadian Clock
Reactome 49
ATF2
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Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367
WikiPathways 50
ATF2
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RAC1 signaling pathway
PID 54
ATF2
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IL5
NetPath 59
ATF2
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ATF-2 transcription factor network
PID 59
ATF2
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TP53 Regulates Transcription of DNA Repair Genes
Reactome 61
ATF2
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IL12-mediated signaling events
PID 62
ATF2
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Hs_TGF-beta_Signaling_Pathway_WP366_90028
WikiPathways 67
ATF2
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Regulation of retinoblastoma protein
PID 67
ATF2
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IL1
NetPath 69
ATF2
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Ras Pathway
PANTHER 69
ATF2
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AP-1 transcription factor network
PID 71
ATF2
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CDC42 signaling events
PID 71
ATF2
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IL4
NetPath 75
ATF2
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IL2
NetPath 81
ATF2
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TSH
NetPath 82
ATF2
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Regulation of nuclear SMAD2/3 signaling
PID 82
ATF2
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IL3
NetPath 84
ATF2
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RANKL
NetPath 84
ATF2
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TGF-beta signaling pathway
PANTHER 88
ATF2
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Leptin
NetPath 98
ATF2
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KitReceptor
NetPath 104
ATF2
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Apoptosis signaling pathway
PANTHER 104
ATF2
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ErbB1 downstream signaling
PID 105
ATF2
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HATs acetylate histones
Reactome 142
ATF2
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Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
WikiPathways 153
ATF2
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BCR
NetPath 161
ATF2
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AndrogenReceptor
NetPath 167
ATF2
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TGF_beta_Receptor
NetPath 220
ATF2
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TCR
NetPath 261
ATF2
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MAPK signaling pathway
KEGG 264
Target Gene Expression Analysis
Expression Atlas of ATF2