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T(co)F Overview
T(co)F: STAT3
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: STAT domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: OE21
Tissue Type: Oesophagus
Biosample Type: Cell line
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE47763
Platform: GPL10558
Pubmed ID: 23912451

STAT3- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of STAT3
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of STAT3

Upstream Pathway Annotation of STAT3
T(co)F Pathway Name Source Gene Number
STAT3
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Hs_Amino_Acid_metabolism_WP3925_90737
WikiPathways 6
STAT3
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IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) )
INOH 6
STAT3
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IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) )
INOH 6
STAT3
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IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) )
INOH 6
STAT3
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Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )
INOH 8
STAT3
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Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )
INOH 8
STAT3
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Hs_RalA_downstream_regulated_genes_WP2290_79988
WikiPathways 9
STAT3
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LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) )
INOH 10
STAT3
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Interleukin-6 signaling
Reactome 11
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling by Leptin
Reactome 11
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-9_Signaling_Pathway_WP22_79264
WikiPathways 11
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_PDGF_Pathway_WP2526_82681
WikiPathways 12
STAT3
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EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
INOH 12
STAT3
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POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome 13
STAT3
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Hs_ESC_Pluripotency_Pathways_WP3931_91005
WikiPathways 13
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) )
INOH 13
STAT3
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Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )
INOH 14
STAT3
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Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946
WikiPathways 15
STAT3
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JAK/STAT signaling pathway
PANTHER 15
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Notch_Signaling_Pathway_WP61_78592
WikiPathways 16
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Interleukin-11_Signaling_Pathway_WP2332_79525
WikiPathways 17
STAT3
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Signaling by cytosolic FGFR1 fusion mutants
Reactome 18
STAT3
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IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) )
INOH 18
STAT3
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Hs_Dopaminergic_Neurogenesis_WP2855_87239
WikiPathways 19
STAT3
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IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) )
INOH 19
STAT3
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Growth hormone receptor signaling
Reactome 24
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL9
NetPath 24
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
TSLP
NetPath 24
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-6_signaling_pathway_WP364_89832
WikiPathways 26
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL27-mediated signaling events
PID 26
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Transcriptional regulation of pluripotent stem cells
Reactome 28
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL-7
NetPath 28
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Downstream signal transduction
Reactome 29
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794
WikiPathways 29
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Vitamin_B12_Metabolism_WP1533_85340
WikiPathways 33
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-2_Signaling_Pathway_WP49_91243
WikiPathways 33
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL12 signaling mediated by STAT4
PID 33
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Interferon_type_I_signaling_pathways_WP585_85198
WikiPathways 35
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-5_Signaling_Pathway_WP127_78498
WikiPathways 35
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-3_Signaling_Pathway_WP286_78583
WikiPathways 35
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640
WikiPathways 36
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling by SCF-KIT
Reactome 37
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Leptin_signaling_pathway_WP2034_89856
WikiPathways 37
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL23-mediated signaling events
PID 37
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Regulation_of_Microtubule_Cytoskeleton_WP2038_90889
WikiPathways 38
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
GMCSF-mediated signaling events
PID 38
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Association of TriC/CCT with target proteins during biosynthesis
Reactome 39
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling events mediated by TCPTP
PID 40
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_IL-4_Signaling_Pathway_WP395_89828
WikiPathways 41
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
ErbB2/ErbB3 signaling events
PID 41
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IFN-gamma pathway
PID 43
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668
WikiPathways 44
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Kit_receptor_signaling_pathway_WP304_78799
WikiPathways 46
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL6-mediated signaling events
PID 48
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Notch-mediated HES/HEY network
PID 48
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Acute myeloid leukemia
KEGG 53
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling events mediated by PTP1B
PID 53
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling events mediated by Stem cell factor receptor (c-Kit)
PID 53
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL2-mediated signaling events
PID 54
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
RAC1 signaling pathway
PID 54
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
FGF signaling pathway
PID 55
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL5
NetPath 59
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL12-mediated signaling events
PID 62
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Neurotrophic factor-mediated Trk receptor signaling
PID 63
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Adipocytokine signaling pathway
KEGG 65
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL1
NetPath 69
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Ras Pathway
PANTHER 69
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Pancreatic cancer
KEGG 70
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL4
NetPath 75
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Notch
NetPath 76
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803
WikiPathways 80
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL2
NetPath 81
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
TSH
NetPath 82
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL3
NetPath 84
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
IL6
NetPath 85
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Interleukin signaling pathway
PANTHER 86
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
CXCR4-mediated signaling events
PID 87
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Signaling events mediated by HDAC Class I
PID 89
STAT3
Warning: Undefined variable $tf_pathway_species in /data/html/KnockTF/search/search_sample_result.php on line 779

Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram )
INOH 97
STAT3
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Warning: Undefined variable $snp_id in /data/html/KnockTF/search/search_sample_result.php on line 779
Leptin
NetPath 98
STAT3
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KitReceptor
NetPath 104
STAT3
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Prolactin
NetPath 105
STAT3
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ErbB1 downstream signaling
PID 105
STAT3
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Hs_EGF-EGFR_Signaling_Pathway_WP437_79266
WikiPathways 107
STAT3
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Senescence-Associated Secretory Phenotype (SASP)
Reactome 108
STAT3
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EGF receptor signaling pathway
PANTHER 109
STAT3
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PDGF signaling pathway
PANTHER 113
STAT3
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PDGFR-beta signaling pathway
PID 125
STAT3
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Toxoplasmosis
KEGG 131
STAT3
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Hepatitis C
KEGG 134
STAT3
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Angiogenesis
PANTHER 141
STAT3
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Jak-STAT signaling pathway
KEGG 149
STAT3
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Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
WikiPathways 153
STAT3
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BCR
NetPath 161
STAT3
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AndrogenReceptor
NetPath 167
STAT3
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Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
INOH 178
STAT3
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Chemokine signaling pathway
KEGG 187
STAT3
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Inflammation mediated by chemokine and cytokine signaling pathway
PANTHER 189
STAT3
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Pathways in cancer
KEGG 321
STAT3
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of STAT3