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T(co)F Overview
T(co)F: POU5F1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Homeo domain factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: H1-hESC
Tissue Type: Embryo
Biosample Type: Stem cell
# of Control: 8
# of Treat: 8
Data Source: GEO
Profile ID: GSE34904
Platform: GPL10558
Pubmed ID: 22482508

POU5F1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of POU5F1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of POU5F1

Upstream Pathway Annotation of POU5F1
T(co)F Pathway Name Source Gene Number
POU5F1
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POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Reactome 10
POU5F1
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Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291
WikiPathways 12
POU5F1
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POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome 13
POU5F1
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Transcriptional regulation of pluripotent stem cells
Reactome 28
POU5F1
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HIF-2-alpha transcription factor network
PID 34
POU5F1
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Hs_Endoderm_Differentiation_WP2853_88152
WikiPathways 62
Target Gene Expression Analysis
Expression Atlas of POU5F1