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T(co)F Overview
T(co)F: MITF
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic helix-loop-helix factors (bHLH)
T(co)F Superclass: Basic domains
Biosample Name: A375
Tissue Type: Skin
Biosample Type: Cell line
# of Control: 3
# of Treat: 1
Data Source: GEO
Profile ID: GSE31534
Platform: GPL570
Pubmed ID: 22536322

MITF- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of MITF
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of MITF

Upstream Pathway Annotation of MITF
T(co)F Pathway Name Source Gene Number
MITF
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SUMOylation of transcription factors
Reactome 14
MITF
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Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016
WikiPathways 26
MITF
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Signaling mediated by p38-alpha and p38-beta
PID 35
MITF
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Hs_Neural_Crest_Differentiation_WP2064_79263
WikiPathways 40
MITF
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Hs_Kit_receptor_signaling_pathway_WP304_78799
WikiPathways 46
MITF
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IL6-mediated signaling events
PID 48
MITF
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Signaling events mediated by Stem cell factor receptor (c-Kit)
PID 53
MITF
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Regulation of retinoblastoma protein
PID 67
MITF
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Melanoma
KEGG 69
MITF
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Regulation of nuclear beta catenin signaling and target gene transcription
PID 80
MITF
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RANKL
NetPath 84
MITF
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Melanogenesis
KEGG 100
MITF
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KitReceptor
NetPath 104
MITF
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Pathways in cancer
KEGG 321
Target Gene Expression Analysis
Expression Atlas of MITF