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T(co)F Overview
T(co)F: CREB1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 10
# of Treat: 10
Data Source: GEO
Profile ID: GSE12056
Platform: GPL570
Pubmed ID: 18801183

CREB1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of CREB1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of CREB1

Upstream Pathway Annotation of CREB1
T(co)F Pathway Name Source Gene Number
CREB1
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CaMK IV-mediated phosphorylation of CREB
Reactome 5
CREB1
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CREB phosphorylation through the activation of CaMKK
Reactome 6
CREB1
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CREB phosphorylation
Reactome 7
CREB1
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CREB phosphorylation through the activation of Adenylate Cyclase
Reactome 7
CREB1
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Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
SMPDB 7
CREB1
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Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
SMPDB 7
CREB1
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Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
SMPDB 7
CREB1
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Intracellular Signalling Through Histamine H2 Receptor and Histamine
SMPDB 8
CREB1
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AKT phosphorylates targets in the nucleus
Reactome 9
CREB1
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Gastrin-CREB signalling pathway via PKC and MAPK
Reactome 9
CREB1
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Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) ( GPCR Adenosine A2A receptor signaling pathway )
INOH 9
CREB1
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Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
SMPDB 10
CREB1
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Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
SMPDB 10
CREB1
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NOTCH2 intracellular domain regulates transcription
Reactome 12
CREB1
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CREB phosphorylation through the activation of Ras
Reactome 13
CREB1
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LPA4-mediated signaling events
PID 16
CREB1
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CREB phosphorylation through the activation of CaMKII
Reactome 17
CREB1
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Enkephalin release
PANTHER 17
CREB1
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p38 signaling mediated by MAPKAP kinases
PID 21
CREB1
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NCAM signaling for neurite out-growth
Reactome 22
CREB1
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Constitutive Signaling by AKT1 E17K in Cancer
Reactome 25
CREB1
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VEGFR3 signaling in lymphatic endothelium
PID 26
CREB1
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Nongenotropic Androgen signaling
PID 31
CREB1
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Trk receptor signaling mediated by the MAPK pathway
PID 34
CREB1
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Vasopressin-regulated water reabsorption
KEGG 35
CREB1
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Signaling mediated by p38-alpha and p38-beta
PID 35
CREB1
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Trk receptor signaling mediated by PI3K and PLC-gamma
PID 36
CREB1
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMPDB 37
CREB1
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMPDB 38
CREB1
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Signaling events regulated by Ret tyrosine kinase
PID 39
CREB1
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BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome 42
CREB1
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Transcriptional activation of mitochondrial biogenesis
Reactome 43
CREB1
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LKB1 signaling events
PID 43
CREB1
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FSH
NetPath 44
CREB1
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FOXA2 and FOXA3 transcription factor networks
PID 45
CREB1
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Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s) ( GPCR Dopamine D1like receptor signaling pathway )
INOH 45
CREB1
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Integrin-linked kinase signaling
PID 46
CREB1
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Circadian Clock
Reactome 49
CREB1
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ATF-2 transcription factor network
PID 59
CREB1
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Validated targets of C-MYC transcriptional repression
PID 63
CREB1
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HIF-1-alpha transcription factor network
PID 67
CREB1
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AP-1 transcription factor network
PID 71
CREB1
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Antigen processing and presentation
KEGG 75
CREB1
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IL2
NetPath 81
CREB1
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TSH
NetPath 82
CREB1
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Regulation of nuclear SMAD2/3 signaling
PID 82
CREB1
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IL3
NetPath 84
CREB1
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RANKL
NetPath 84
CREB1
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Prostate cancer
KEGG 85
CREB1
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Glucocorticoid receptor regulatory network
PID 85
CREB1
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Leptin
NetPath 98
CREB1
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Melanogenesis
KEGG 100
CREB1
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ErbB1 downstream signaling
PID 105
CREB1
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER 126
CREB1
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BCR
NetPath 161
CREB1
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AndrogenReceptor
NetPath 167
CREB1
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Huntington's disease
KEGG 182
CREB1
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TCR
NetPath 261
CREB1
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TNFalpha
NetPath 274
CREB1
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EGFR1
NetPath 475
Target Gene Expression Analysis
Expression Atlas of CREB1