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T(co)F Overview
T(co)F: ESR1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Nuclear receptors with C4 zinc fingers
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE10061
Platform: GPL3921
Pubmed ID: 18631401

ESR1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ESR1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ESR1

Upstream Pathway Annotation of ESR1
T(co)F Pathway Name Source Gene Number
ESR1
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Tamoxifen Action Pathway
SMPDB 10
ESR1
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Tamoxifen Metabolism Pathway
SMPDB 10
ESR1
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Hs_Estrogen_signaling_pathway_WP712_78491
WikiPathways 13
ESR1
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Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687
WikiPathways 16
ESR1
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Nuclear signaling by ERBB4
Reactome 25
ESR1
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Cellular roles of Anthrax toxin
PID 25
ESR1
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Signaling mediated by p38-alpha and p38-beta
PID 35
ESR1
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Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974
WikiPathways 36
ESR1
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Hs_Leptin_signaling_pathway_WP2034_89856
WikiPathways 37
ESR1
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Plasma membrane estrogen receptor signaling
PID 42
ESR1
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FOXM1 transcription factor network
PID 43
ESR1
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LKB1 signaling events
PID 43
ESR1
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FOXA1 transcription factor network
PID 45
ESR1
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Nuclear Receptor transcription pathway
Reactome 51
ESR1
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Signaling events mediated by HDAC Class II
PID 58
ESR1
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ATF-2 transcription factor network
PID 59
ESR1
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Validated nuclear estrogen receptor alpha network
PID 65
ESR1
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Regulation of Telomerase
PID 70
ESR1
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AP-1 transcription factor network
PID 71
ESR1
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Regulation of nuclear SMAD2/3 signaling
PID 82
ESR1
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Leptin
NetPath 98
ESR1
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Prolactin
NetPath 105
ESR1
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Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941
WikiPathways 122
ESR1
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AndrogenReceptor
NetPath 167
ESR1
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TGF_beta_Receptor
NetPath 220
Target Gene Expression Analysis
Expression Atlas of ESR1