5.1 Why are showing no results available somewhere?
Reply: Because there is no corresponding function annotation or no significant annotation results for this TF/gene.
5.2 Why the same TF disrupted by the same knockdown/knockout technique appears in different datasets?
Reply: Because these datasets may be from different profiles, different platforms or different biosamples. In KnockTF, there are two data sources. If data source is GEO, five conditions are used to uniquely determine a dataset, including TF, knockdown/knockout technique, biosample name, series (GSE) and platform (GPL); if data source is ENCODE, four conditions are used to uniquely determine a dataset, including TF, knockdown/knockout technique, biosample name and experiment accession.
5.3 Which kinds of species are stored in the database?
Reply: The current version of KnockTF stores the most abundant human gene expression profile datasets of TF knockdown/knockout. There may be a lot of TF knockdown/knockout data about other species in other data sources. In the next version of KnockTF, we will manually curate more TF knockdown/knockout data with more species and enrich the kinds of species information.
5.4 Why might web pages load slowly?
Reply: KnockTF has advanced storage technology and sufficient bandwidth to meet the needs of most users for the speed of web page loading. However, it is not excluded that few users have poor user experience due to network reasons.