SEdb 2.0
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Gene overview

Strategies/Algorithm: closest Ensembl ID: ENSG00000180053
Gene: NKX2-6 Gene type: protein_coding
Strand: - External links:
Genomic region: chr8:23702451-23706598 Genome Browser:

Super-enhancer search result of gene-based

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SE ID SE Region Sample ID Tissue type Biosample name SE rank Element Common SNP eQTL Risk SNP TFBS CRISPR Cas9 Gene
SE_02_074400730 chr8:23690915-23700494 Sample_02_0744 Embryo ES derived cardiac mesoderm_day5 730 5 325 20 4 18 0 NKX3-1,NKX2-6
SE_02_031600120 chr8:23692831-23724876 Sample_02_0316 Neuroblastoma CHP212 120 2 929 41 6 39 356 NKX2-6,NKX3-1
SE_02_111100030 chr8:23695525-23799461 Sample_02_1111 Other HGrC1_SMAD2/3KO 30 39 3091 166 20 171 356 NKX2-6,NKX3-1
SE_01_002300483 chr8:23695545-23727720 Sample_01_0023 Embryo cardiac-muscle-cell 483 8 912 36 3 39 356 NKX2-6,NKX3-1
SE_02_111000011 chr8:23695586-23763787 Sample_02_1110 Other HGrC1 11 32 1988 137 14 66 356 NKX2-6,NKX3-1
SE_02_074500260 chr8:23695657-23727418 Sample_02_0745 Embryo ES derived cardiac progenitor cells_day7 260 10 902 36 3 39 356 NKX2-6,NKX3-1
SE_02_031400162 chr8:23696228-23762405 Sample_02_0314 Neuroblastoma SK-N-FI 162 10 1928 136 14 65 356 NKX2-6,NKX3-1
SE_02_074600905 chr8:23696537-23727422 Sample_02_0746 Embryo ES derived primitive cardiomyocite_day15 905 8 876 35 3 39 356 NKX2-6,NKX3-1
SE_02_110900231 chr8:23701986-23746971 Sample_02_1109 Brain SK-N-FI 231 25 1259 83 8 28 356 NKX2-6,NKX3-1
SE_02_005400881 chr8:23714004-23764430 Sample_02_0054 Lung IMR-90_DMSO_1 881 8 1477 117 13 37 0 NKX3-1,NKX2-6
SE_02_076200975 chr8:23714169-23764659 Sample_02_0762 Podocyte podocyte_CTL 975 11 1482 117 13 37 0 NKX3-1,NKX2-6
SE_02_050000363 chr8:23714181-23765480 Sample_02_0500 Fetal lung IMR90_#2 363 29 1521 117 13 46 0 NKX3-1,NKX2-6,STC1
SE_02_049900622 chr8:23714234-23763696 Sample_02_0499 Fetal lung IMR90 IR Senescence 622 16 1453 117 13 37 0 NKX3-1,NKX2-6,STC1
SE_02_127901694 chr8:23714246-23762709 Sample_02_1279 Bone Mesenchymal stem cells 1694 16 1423 116 13 37 0 NKX3-1,NKX2-6
SE_02_027400670 chr8:23714266-23764188 Sample_02_0274 Endometriosis hTERT_KD 670 9 1467 117 13 37 0 NKX3-1,NKX2-6
SE_02_072701107 chr8:23714317-23764341 Sample_02_0727 Fetal lung IMR90_Etoposide 1107 11 1466 116 13 37 0 NKX3-1,NKX2-6,STC1
SE_02_137700617 chr8:23714335-23764626 Sample_02_1377 Pancreas Pancreatic_tumor_associated_fibroblasts_BF1_untreated 617 20 1476 116 13 37 0 NKX3-1,NKX2-6
SE_02_156600734 chr8:23714354-23762627 Sample_02_1566 Dermal Dermal fibroblast 734 21 1418 115 13 37 0 NKX3-1,NKX2-6,STC1
SE_02_086700987 chr8:23714381-23762099 Sample_02_0867 Bone marrow Bone marrow derived hMSC_d0 987 20 1405 115 13 34 0 NKX3-1,NKX2-6
SE_04_001000392 chr8:23717196-23763086 Sample_04_0010 Lung A549 TGFb 392 10 1361 113 13 31 0 NKX3-1,NKX2-6
SE_02_028100132 chr8:23717934-23763131 Sample_02_0281 Bone U2OS 132 4 1341 111 12 31 0 NKX3-1,NKX2-6
SE_02_139900403 chr8:23718134-23764569 Sample_02_1399 Bone U2OS_siMLL3.1 403 19 1379 111 12 31 0 NKX3-1,NKX2-6
SE_02_048100967 chr8:23718467-23765483 Sample_02_0481 Mammary gland MDA-MB231 967 22 1402 110 12 40 0 NKX3-1,NKX2-6
SE_02_113600555 chr8:23718562-23762834 Sample_02_1136 Bone U2OS-anaphase/telophase 555 10 1310 109 12 31 0 NKX3-1,NKX2-6
SE_02_126301237 chr8:23719084-23763004 Sample_02_1263 Bone Im-GCT-4072_G34W unedited 1237 12 1301 110 12 31 0 NKX3-1,NKX2-6
SE_02_011200173 chr8:23719545-23764568 Sample_02_0112 Connective tissue HT1080_untreated 173 6 1340 110 12 31 0 NKX3-1,NKX2-6
SE_02_087901026 chr8:23719680-23763022 Sample_02_0879 Ovary SVOG3e cells_Dox_12h_control 1026 6 1292 110 12 29 0 NKX3-1,NKX2-6
SE_02_113700613 chr8:23719710-23763130 Sample_02_1137 Retinal Pigmented Epithelial RPE1-interphase 613 12 1294 110 12 29 0 NKX3-1,NKX2-6
SE_02_113900816 chr8:23719766-23763587 Sample_02_1139 Retinal Pigmented Epithelial RPE1-anaphase/telophase 816 10 1303 110 12 29 0 NKX3-1,NKX2-6
SE_02_087801147 chr8:23719773-23763208 Sample_02_0878 Ovary SVOG3e cells_noDox_control 1147 6 1291 110 12 29 0 NKX3-1,NKX2-6
SE_02_132200370 chr8:23719879-23764776 Sample_02_1322 Connective Tissue HT1080_WT 370 16 1330 110 12 31 0 NKX3-1,NKX2-6
SE_02_113800653 chr8:23720048-23763514 Sample_02_1138 Retinal Pigmented Epithelial RPE1-prometaphase 653 10 1290 110 12 29 0 NKX3-1,NKX2-6
SE_02_020900777 chr8:23720274-23763900 Sample_02_0209 Lung MRC-5_MRC5_1DPT 777 12 1300 110 12 29 0 NKX3-1,NKX2-6
SE_02_093800738 chr8:23720464-23762722 Sample_02_0938 Retinal Pigmented Epithelial RPE190_TnT 738 6 1257 109 12 29 0 NKX3-1,NKX2-6
SE_02_093600427 chr8:23720575-23762680 Sample_02_0936 Retinal Pigmented Epithelial RPE188_TnT 427 10 1249 109 12 29 0 NKX3-1,NKX2-6
SE_02_137801130 chr8:23720748-23763725 Sample_02_1378 Pancreas Pancreatic_tumor_associated_fibroblasts_CAF08_untreated 1130 16 1281 110 12 29 0 NKX3-1,NKX2-6
SE_02_084600652 chr8:23720760-23762739 Sample_02_0846 Mammary gland MDA-MB-231_untreat 652 14 1250 109 12 29 0 NKX3-1,NKX2-6
SE_02_127200879 chr8:23740099-23762965 Sample_02_1272 Leiomyosarcoma SK-LMS-1_HDAC4KO 879 9 708 76 9 27 0 NKX2-6,NKX3-1
SE_02_011300508 chr8:23743464-23763853 Sample_02_0113 Connective tissue HT1080_DOX5d 508 3 637 62 9 27 0 NKX2-6,NKX3-1
SE_02_088201278 chr8:23743777-23763652 Sample_02_0882 Ovary SVOG3e_cells_noDox_transduced with V5-FOXL2 C134W 1278 5 618 59 9 27 0 NKX2-6,NKX3-1
SE_02_047400613 chr8:23743896-23763563 Sample_02_0474 Fibroblast umbilical cord Fibroblast 613 9 607 59 9 27 0 NKX2-6
SE_02_132000925 chr8:23743978-23764453 Sample_02_1320 Connective Tissue HT1080_EWS-FLI1 925 10 631 59 9 27 0 NKX2-6,NKX3-1
SE_02_045100931 chr8:23744030-23764226 Sample_02_0451 Skin in vitro transformedskin fibroblasts_tumourigenic 931 6 622 59 9 27 0 NKX2-6,NKX3-1
SE_02_017300219 chr8:23744439-23765899 Sample_02_0173 Lung IMR-90_senescent 219 7 679 58 9 36 0 NKX2-6
SE_02_116600632 chr8:23744442-23762460 Sample_02_1166 Biliary H69_TGF beta_16h_1 632 9 569 57 9 26 0 NKX2-6
SE_02_116900640 chr8:23744487-23762354 Sample_02_1169 Biliary H69_TGF beta_16h_2 640 8 563 57 9 26 0 NKX2-6
SE_02_022900451 chr8:23744503-23762516 Sample_02_0229 Umbilical cord ID01 451 7 569 57 9 26 0 NKX2-6
SE_02_137901281 chr8:23744546-23762415 Sample_02_1379 Pancreas Pancreatic_tumor_associated_fibroblasts_PS1_untreated 1281 6 563 57 9 26 0 NKX2-6,NKX3-1
SE_02_132100830 chr8:23744610-23764493 Sample_02_1321 Connective Tissue HT1080_FUS-DDIT3 830 10 622 58 9 27 0 NKX2-6,NKX3-1
SE_02_023000395 chr8:23744615-23762292 Sample_02_0230 Umbilical cord ID60 395 7 561 57 9 26 0 NKX2-6,NKX3-1
SE_02_141800367 chr8:23744649-23764551 Sample_02_1418 Brain SF9427 367 5 624 58 9 27 0 NKX2-6
SE_02_017500347 chr8:23744685-23763694 Sample_02_0175 Lung IMR-90_Etoposide 347 7 598 58 9 27 0 NKX2-6,NKX3-1
SE_02_027000411 chr8:23745451-23764104 Sample_02_0270 Kidney PCS-400 411 5 587 52 9 27 0 NKX2-6,STC1
SE_02_145800321 chr8:23750400-23765534 Sample_02_1458 Pancreas THP1+PANC1_shNC 321 6 494 36 4 36 0 NKX2-6,NKX3-1
SE_02_007200057 chr8:23760930-23775293 Sample_02_0072 Lung NCI-H82_DMSO 57 4 450 5 2 44 0 NKX2-6
Genomic distribution of SEs associated with NKX2-6
Genome Browser

The strength of the tissue affected by the gene

Expression of NKX2-6

Cell line (ENCODE) Primary cell (ENCODE)Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)