Super-enhancers are a large cluster of transcriptionally active enhancers enriched in enhancer-associated chromatin characteristics. Compared to typical enhancers, super-enhancers are larger, exhibit higher transcription factor density, and are frequently associated with key lineage-specific genes that control cell state and differentiation in somatic cells.
Here, we developed a comprehensive human and mouse super-enhancer database (SEdb 2.0, http://www.licpathway.net/sedb) that aimed to provide a large number of available resources on human and mouse super-enhancers. The database was annotated with potential functions of super-enhancers in the TF-gene regulation. The current version of SEdb 2.0 documented a total of 1,717,744 SEs from 2,670 samples including 1,739 human samples and 931 mouse samples. Furthermore, SEdb 2.0 provides detailed genetic and epigenetic annotation information on super-enhancers. Information includes common SNPs, motif changes, expression quantitative trait locus (eQTL), risk SNPs, transcription factor binding sites (TFBSs), CRISPR/Cas9 target sites, DNase I hypersensitivity sites (DHSs), chromatin accessibility regions, methylation sites, chromatin interactions regions and TADs. For in-depth analyses of super-enhancers, SEdb 2.0 will help elucidate super-enhancer-related functions and find potential biological effects.
The current version of SEdb 2.0 documented 1,717,744 SEs from 2,670 samples, including 541 original human samples, 1,198 newly released human samples and 931 mouse samples, including the samples from NCBI GEO/SRA, ENCODE, Roadmap, GGR and NGDC GSA. For all samples, super-enhancers were identified by using a unified system environment and software parameters.
For more detailed statistics, please see the "Statistics" page.