SEdb 2.0
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  2. Super-enhancer search result of gene-based

Gene overview

Strategies/Algorithm: closest Ensembl ID: ENSG00000136244
Gene: IL6 Gene type: protein_coding
Strand: + External links:
Genomic region: chr7:22725884-22732002 Genome Browser:

Super-enhancer search result of gene-based

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SE ID SE Region Sample ID Tissue type Biosample name SE rank Element Common SNP eQTL Risk SNP TFBS CRISPR Cas9 Gene
SE_02_011000041 chr7:22559448-22677518 Sample_02_0110 Ovaries IOE11 41 11 3055 126 12 165 491 IL6
SE_01_005600012 chr7:22559668-22672642 Sample_01_0056 Bone osteoblast 12 18 2931 111 12 165 491 IL6
SE_01_001900295 chr7:22626546-22669097 Sample_01_0019 Brain and spinal cord astrocyte 295 6 1179 48 5 68 0 IL6
SE_02_002700558 chr7:22630813-22676892 Sample_02_0027 Umbilical vein HUVEC_VEGF_4h 558 9 1255 64 7 68 0 IL6
SE_01_002600114 chr7:22631263-22677595 Sample_01_0026 Umbilical vein endothelial-cell-of-umbilical-vein 114 6 1265 66 7 68 0 IL6
SE_02_017500559 chr7:22632330-22676834 Sample_02_0175 Lung IMR-90_Etoposide 559 18 1220 63 7 68 0 IL6
SE_02_005300019 chr7:22646119-22733520 Sample_02_0053 Colon DKO1 19 21 2606 216 17 184 671 IL6
SE_02_005400725 chr7:22646174-22676920 Sample_02_0054 Lung IMR-90_DMSO_1 725 6 850 48 6 47 0 IL6
SE_02_005500811 chr7:22646304-22676815 Sample_02_0055 Lung IMR-90_Nutlin-3a 811 5 841 46 6 47 0 IL6
SE_02_043000426 chr7:22646406-22669326 Sample_02_0430 Kidney 12364284 426 9 661 26 5 47 0 IL6
SE_01_005800859 chr7:22646677-22676701 Sample_01_0058 Prostate PC-3 859 5 824 45 6 47 0 IL6
SE_02_003900408 chr7:22651030-22681643 Sample_02_0039 Embryo AFG 408 4 856 61 6 51 0 IL6
SE_01_002000069 chr7:22657592-22730962 Sample_01_0020 Blood B-cell 69 11 2182 205 16 162 599 IL6
SE_00_000500050 chr7:22657677-22728929 Sample_00_0005 Blood B-cell 50 11 2125 201 16 155 421 IL6
SE_02_038700304 chr7:22658025-22682388 Sample_02_0387 Lymph node CD19+_B_cells_nhl_FL1-2 304 11 665 54 6 40 0 IL6
SE_02_002500168 chr7:22658955-22681491 Sample_02_0025 Blood CD19donorA 168 8 617 51 6 33 0 IL6
SE_01_008401191 chr7:22659289-22731707 Sample_01_0084 Spleen spleen 1191 15 2146 202 17 160 655 IL6
SE_02_012400201 chr7:22661825-22699390 Sample_02_0124 Embryo Embryonic-stem-cells_Naive 201 4 1047 89 8 44 0 IL6
SE_02_006500769 chr7:22662012-22673806 Sample_02_0065 Embryo KO2-Late_G1 769 3 312 27 5 19 0 IL6
SE_02_004001267 chr7:22666235-22676373 Sample_02_0040 Embryo PFG 1267 3 256 28 3 7 0 IL6
SE_02_003800592 chr7:22666555-22676615 Sample_02_0038 Embryo DE 592 3 254 27 3 5 0 IL6
SE_02_142300033 chr7:22675866-22717970 Sample_02_1423 Haematopoietic and lymphoid tissue bone marrow K562_Triptolide_1h 33 14 1321 129 4 58 0 LOC541472,LOC401312,IL6,TOMM7
SE_02_002500419 chr7:22694130-22723904 Sample_02_0025 Blood CD19donorA 419 10 971 99 4 70 0 IL6
SE_02_103300065 chr7:22694301-22711182 Sample_02_1033 Haematopoietic and lymphoid tissue bone marrow K562 65 1 574 57 0 9 0 LOC541472,LOC401312,IL6,TOMM7
SE_02_127800012 chr7:22694366-22733066 Sample_02_1278 Chordoma UCH1_DMSO_48h 12 4 1234 123 8 121 671 IL6,LOC541472,LOC401312
SE_02_038700389 chr7:22695036-22724784 Sample_02_0387 Lymph node CD19+_B_cells_nhl_FL1-2 389 12 976 101 4 70 0 IL6
SE_02_061500062 chr7:22695075-22731618 Sample_02_0615 Liposarcoma liposarcoma cells_MLS402 62 7 1174 121 7 112 647 IL6,LOC541472,LOC401312
SE_01_005400257 chr7:22695168-22728607 Sample_01_0054 Haematopoietic and lymphoid tissue OCI-LY3 257 3 1086 116 6 100 388 IL6
SE_02_101700959 chr7:22695332-22721387 Sample_02_1017 Embryo H9_Mesendoderm 24h_Hydroxyurea 959 5 870 95 3 52 0 LOC541472,LOC401312,IL6
SE_02_054700086 chr7:22696006-22709964 Sample_02_0547 Bone marrow K562_MYO1D_Hub_KO 86 4 480 46 0 9 0 LOC541472,LOC401312,IL6
SE_02_142200092 chr7:22696463-22709940 Sample_02_1422 Haematopoietic and lymphoid tissue bone marrow K562_Triptolide_0h 92 5 465 46 0 9 0 LOC541472,LOC401312,IL6
SE_02_003801031 chr7:22696465-22718997 Sample_02_0038 Embryo DE 1031 6 759 82 3 47 0 IL6
SE_00_002400268 chr7:22696536-22728436 Sample_00_0024 Embryo mesendoderm 268 11 1033 109 6 100 375 IL6
SE_02_101600507 chr7:22696545-22722062 Sample_02_1016 Embryo H9_Mesendoderm_24h 507 7 844 94 3 54 0 LOC541472,LOC401312,IL6
SE_02_142400097 chr7:22696646-22709902 Sample_02_1424 Haematopoietic and lymphoid tissue bone marrow K562_Triptolide_4h 97 5 457 46 0 9 0 LOC541472,LOC401312,IL6
SE_02_154900272 chr7:22696707-22731794 Sample_02_1549 Gastrointestinal Stromal GIST-430B 272 5 1125 117 8 119 655 IL6,LOC541472,LOC401312
SE_04_000100777 chr7:22699959-22710146 Sample_04_0001 Blood heat shocked K562 777 1 367 41 0 0 0 LOC541472,LOC401312,IL6
SE_04_000200372 chr7:22699983-22710598 Sample_04_0002 Blood cold shocked K562 372 1 381 43 0 0 0 LOC541472,LOC401312,IL6,TOMM7
SE_02_054500260 chr7:22700092-22710565 Sample_02_0545 Bone marrow K562 WT 260 1 375 43 0 0 0 LOC541472,LOC401312,IL6,TOMM7
SE_02_006500829 chr7:22700237-22711028 Sample_02_0065 Embryo KO2-Late_G1 829 2 394 48 0 0 0 IL6
SE_02_075200527 chr7:22700331-22710773 Sample_02_0752 Embryo ES-derived progenitors_DE_wild type 527 2 380 45 0 0 0 LOC541472,LOC401312,IL6
SE_02_075500634 chr7:22701253-22711294 Sample_02_0755 Embryo ES-derived progenitors_DE FOXA2 -/- 634 2 375 46 0 0 0 LOC541472,LOC401312,IL6
SE_02_156701241 chr7:22701638-22710191 Sample_02_1567 iPSCs CiPSC 1241 7 312 36 0 0 0 LOC541472,LOC401312,IL6
SE_02_075600828 chr7:22701708-22721723 Sample_02_0756 Embryo ES-derived progenitors_FG FOXA2 -/- 828 5 673 84 3 43 0 LOC541472,LOC401312,IL6
SE_02_086000343 chr7:22701931-22710051 Sample_02_0860 iPSCs SAH_SMARCB1_K364del/+ 343 3 299 35 0 0 0 LOC541472,LOC401312,IL6
SE_02_075300463 chr7:22702007-22710989 Sample_02_0753 Embryo ES-derived progenitors_FG type 463 4 333 42 0 0 0 LOC541472,LOC401312,IL6
SE_02_004300613 chr7:22702064-22710218 Sample_02_0043 Embryo endodermal CyT49_ES_D2 613 6 301 34 0 0 0 IL6
SE_02_074300252 chr7:22702362-22710122 Sample_02_0743 Embryo ES derived mesoderm_day2 252 3 292 34 0 0 0 LOC541472,LOC401312,IL6
SE_02_049901494 chr7:22702366-22731882 Sample_02_0499 Fetal lung IMR90 IR Senescence 1494 12 955 105 8 112 660 IL6,LOC541472,LOC401312
SE_02_055900602 chr7:22702932-22709990 Sample_02_0559 iPSCs FX52 iPSCs dC-T 602 2 271 32 0 0 0 LOC541472,LOC401312,IL6
SE_02_074400482 chr7:22703056-22710074 Sample_02_0744 Embryo ES derived cardiac mesoderm_day5 482 4 271 32 0 0 0 LOC541472,LOC401312,IL6
SE_02_056000242 chr7:22703103-22710071 Sample_02_0560 iPSCs FX52_Cas9-inactive Tet1_CGG sgRNA 242 5 269 32 0 0 0 LOC541472,LOC401312,IL6
SE_02_072700817 chr7:22703142-22731661 Sample_02_0727 Fetal lung IMR90_Etoposide 817 5 927 103 7 104 653 IL6,LOC541472,LOC401312
SE_02_038600128 chr7:22709278-22723334 Sample_02_0386 Lymph node CD19+_B_cells_FL1-2 128 3 444 52 3 55 0 IL6
SE_02_141500278 chr7:22714920-22731606 Sample_02_1415 Brain DIPGIV 278 5 492 52 7 94 647 IL6,LOC541472,LOC401312
SE_02_057200220 chr7:22714984-22731961 Sample_02_0572 Brain LN229_1_mM_glucose 220 6 498 52 8 104 664 IL6,LOC541472,LOC401312
SE_02_058800201 chr7:22715124-22730866 Sample_02_0588 Cervix HeLa Kyoto_untreated 201 9 466 52 7 94 599 IL6,LOC541472,LOC401312
SE_02_001100229 chr7:22715160-22731453 Sample_02_0011 Kidney A-498_wtVHL 229 5 481 51 7 94 624 IL6
SE_01_001800505 chr7:22716119-22731918 Sample_01_0018 Submandibular Salivary Gland ACC112 505 3 463 50 8 102 664 IL6
SE_02_048101011 chr7:22716180-22733149 Sample_02_0481 Mammary gland MDA-MB231 1011 4 505 53 8 102 671 IL6,LOC541472
SE_02_127900886 chr7:22716328-22732998 Sample_02_1279 Bone Mesenchymal stem cells 886 5 492 51 8 91 671 IL6,LOC541472
SE_02_011000849 chr7:22716333-22732126 Sample_02_0110 Ovaries IOE11 849 2 467 49 8 90 671 IL6
SE_02_126301360 chr7:22716453-22731780 Sample_02_1263 Bone Im-GCT-4072_G34W unedited 1360 4 450 46 8 87 655 IL6,LOC541472
SE_02_094900697 chr7:22716546-22731041 Sample_02_0949 Umbilical artery HUAEC_WT 697 5 429 46 7 80 599 IL6,LOC541472
SE_02_154800592 chr7:22716599-22731924 Sample_02_1548 Gastrointestinal Stromal GIST-226 592 5 447 46 8 90 664 IL6,LOC541472
SE_02_045100446 chr7:22716629-22731707 Sample_02_0451 Skin in vitro transformedskin fibroblasts_tumourigenic 446 4 444 46 8 84 655 IL6,LOC541472
SE_01_005600522 chr7:22716641-22732119 Sample_01_0056 Bone osteoblast 522 4 455 46 8 90 671 IL6
SE_02_142800253 chr7:22716651-22731593 Sample_02_1428 Shoulder fibroblast_316 253 3 440 46 7 80 644 IL6,LOC541472
SE_01_002600827 chr7:22716738-22729641 Sample_01_0026 Umbilical vein endothelial-cell-of-umbilical-vein 827 3 388 45 7 79 459 IL6
SE_02_126500729 chr7:22716739-22732026 Sample_02_1265 Bone Im-GCT-4072_G34W-repair_WT_D6 729 4 450 46 8 90 667 IL6,LOC541472
SE_02_039500656 chr7:22716784-22734655 Sample_02_0395 Mammary gland BT-549 656 4 536 52 8 90 671 IL6
SE_02_086701017 chr7:22716853-22731129 Sample_02_0867 Bone marrow Bone marrow derived hMSC_d0 1017 10 421 45 6 80 599 IL6,LOC541472
SE_02_057100511 chr7:22716854-22731296 Sample_02_0571 Brain LN229_1mM_glucose_5mM_acetate 511 6 428 45 6 80 605 IL6,LOC541472
SE_02_045201164 chr7:22716859-22731357 Sample_02_0452 Skin hTERT immortalised human skin fibroblasts_Non-tumourigenic 1164 3 429 45 6 80 615 IL6,LOC541472
SE_02_076300937 chr7:22716900-22731741 Sample_02_0763 Podocyte podocyte_DEX 937 2 436 45 7 86 655 IL6,LOC541472
SE_02_126700844 chr7:22716948-22731954 Sample_02_1267 Bone Im-GCT-4072_G34W 844 4 438 44 7 90 664 IL6,LOC541472
SE_02_027400878 chr7:22716966-22731795 Sample_02_0274 Endometriosis hTERT_KD 878 3 436 44 7 86 655 IL6
SE_02_142700737 chr7:22716983-22731366 Sample_02_1427 Shoulder fibroblast_343 737 9 426 44 6 78 618 IL6,LOC541472
SE_02_126401219 chr7:22716997-22731981 Sample_02_1264 Bone Im-GCT-4072_G34W KO 1219 3 437 44 7 88 665 IL6,LOC541472
SE_02_060900166 chr7:22716999-22731699 Sample_02_0609 Liposarcoma LPS141 166 5 433 44 7 81 655 IL6,LOC541472
SE_02_026300516 chr7:22717016-22732107 Sample_02_0263 Osteoblastic hFOB_undifferentiated 516 3 444 44 7 88 671 IL6
SE_02_056900868 chr7:22717016-22734594 Sample_02_0569 Periodontal ligament mesenchymal stem cell 868 12 521 49 7 88 671 IL6,LOC541472
SE_02_158100456 chr7:22717047-22731350 Sample_02_1581 Renal OS-LM1 456 3 425 44 6 78 613 IL6,LOC541472
SE_02_137900931 chr7:22717070-22731024 Sample_02_1379 Pancreas Pancreatic_tumor_associated_fibroblasts_PS1_untreated 931 5 416 44 6 78 599 IL6,LOC541472
SE_02_124000456 chr7:22717070-22731715 Sample_02_1240 Skin MCC13_virus_negative 456 5 433 44 7 82 655 IL6,LOC541472
SE_02_093900607 chr7:22717079-22731340 Sample_02_0939 Mammary gland MDA-MB-231_control 607 3 425 44 6 78 611 IL6,LOC541472
SE_02_095000850 chr7:22717088-22731654 Sample_02_0950 Umbilical vein HUVEC_WT 850 14 431 44 6 79 652 IL6,LOC541472
SE_01_001900720 chr7:22717147-22731945 Sample_01_0019 Brain and spinal cord astrocyte 720 2 432 44 7 88 664 IL6
SE_02_130900541 chr7:22717170-22731506 Sample_02_1309 Artery Pulmonary artery endothelial cells_Control 541 3 424 44 6 78 635 IL6,LOC541472,TOMM7
SE_02_113300378 chr7:22717205-22732022 Sample_02_1133 Liver Hepatic stellate cells 378 5 433 43 7 88 667 IL6,LOC541472
SE_02_126600818 chr7:22717311-22732065 Sample_02_1266 Bone Im-GCT-4072_G34W-repair_WT_E3 818 3 436 43 7 87 667 IL6,LOC541472
SE_02_158200483 chr7:22717412-22731457 Sample_02_1582 Renal OS-RC-2 483 3 419 43 6 77 626 IL6,LOC541472
SE_02_132800731 chr7:22717418-22731564 Sample_02_1328 Non-mineralized aortic valves aortic valve interstitial cells 731 7 420 43 6 77 640 IL6,LOC541472
SE_02_061001167 chr7:22717419-22731538 Sample_02_0610 Liposarcoma MLS 1765-92 1167 3 420 43 6 77 636 IL6,LOC541472
SE_02_145200878 chr7:22717469-22731922 Sample_02_1452 Arter pulmonary arterial smooth muscle cells_PAH2_sictrl 878 5 426 43 7 87 664 IL6,LOC541472
SE_02_138000459 chr7:22717481-22731280 Sample_02_1380 Pancreas Pancreatic_tumor_associated_fibroblasts_CW1_untreated 459 5 414 42 6 77 604 IL6,LOC541472
SE_02_142600524 chr7:22717496-22730517 Sample_02_1426 Shoulder fibroblast_341 524 6 391 41 6 77 573 IL6,LOC541472
SE_02_137601156 chr7:22717512-22731707 Sample_02_1376 Pancreas Pancreatic_tumor_associated_fibroblasts_B011C_untreated 1156 7 422 42 7 81 655 IL6,LOC541472
SE_02_126100300 chr7:22717526-22732014 Sample_02_1261 Bone Im-GCT-3504_G34W_unedited 300 4 426 42 7 87 667 IL6,LOC541472
SE_02_137500996 chr7:22717555-22731295 Sample_02_1375 Pancreas Pancreatic_tumor_associated_fibroblasts_B0010A_untreated 996 4 410 42 6 77 605 IL6,LOC541472
SE_01_011700751 chr7:22717570-22731231 Sample_01_0117 Lung fibroblast of lung 751 2 408 42 6 77 599 IL6,LOC541472
SE_02_126800846 chr7:22717571-22731288 Sample_02_1268 Bone Im-GCT-4072_G34W unedited_U3 846 2 409 42 6 77 605 IL6,LOC541472
SE_02_086900734 chr7:22717607-22731650 Sample_02_0869 Fibroblast VH10_NO_UV 734 9 416 42 6 78 652 IL6,LOC541472
SE_02_145500831 chr7:22717616-22731887 Sample_02_1455 Arter pulmonary arterial smooth muscle cells_PAH2_sialdh1a3 831 4 420 42 7 87 662 IL6,LOC541472
SE_02_064300601 chr7:22717618-22731204 Sample_02_0643 Mammary gland MDA-MB-436 601 5 406 42 6 77 599 IL6,LOC541472
SE_02_084900568 chr7:22717676-22731258 Sample_02_0849 iPSCs iPSC_CBP-30 568 3 406 42 6 77 601 IL6,LOC541472
SE_02_136400447 chr7:22717678-22731176 Sample_02_1364 Pancreas pancreatic tumor_associated fibroblasts_triptolide_18h 447 3 403 42 6 77 599 IL6,LOC541472
SE_02_145400724 chr7:22717686-22731940 Sample_02_1454 Arter pulmonary arterial smooth muscle cells_PAH1_sialdh1a3 724 5 417 42 7 87 664 IL6,LOC541472
SE_02_126200378 chr7:22717692-22730653 Sample_02_1262 Bone Im-GCT-3504_G34W 378 5 387 42 6 77 594 IL6,LOC541472
SE_02_135300763 chr7:22717696-22731912 Sample_02_1353 Mammary gland MDA-MB-231-Erbeta_TNFa 763 2 417 42 7 87 663 IL6,LOC541472
SE_02_061301158 chr7:22717697-22731596 Sample_02_0613 Liposarcoma MLPS_T1 1158 6 411 42 6 77 644 IL6,LOC541472
SE_02_142500683 chr7:22717763-22731222 Sample_02_1425 Shoulder fibroblast_384 683 3 402 41 6 75 599 IL6,LOC541472
SE_02_064200712 chr7:22717763-22731299 Sample_02_0642 Mammary gland MDA-MB-436_20C paclitaxel 712 7 404 41 6 75 605 IL6,LOC541472
SE_02_122700293 chr7:22717781-22731652 Sample_02_1227 Bone marrow U266 293 6 409 41 6 76 652 IL6,LOC541472
SE_02_135100535 chr7:22717833-22731859 Sample_02_1351 Mammary gland MDA-MB-231-Erbeta_vehicle 535 2 412 41 7 82 658 IL6,LOC541472
SE_02_102500904 chr7:22718455-22733288 Sample_02_1025 Esophagus KYSE150 904 7 439 41 6 74 671 IL6,LOC541472
SE_02_117400343 chr7:22720900-22731636 Sample_02_1174 Brain GBM02 343 5 311 26 4 64 649 IL6,LOC541472
SE_02_079100129 chr7:22721502-22731141 Sample_02_0791 Brain 2455 129 3 285 25 4 59 599 IL6,LOC541472
Genomic distribution of SEs associated with IL6
Genome Browser

The strength of the tissue affected by the gene

Expression of IL6

Cell line (ENCODE) Primary cell (ENCODE)Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)