About Enhancer
| Enhancer ID: | E_02_267 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr17:35501113-35507015   |
|
| Biosample name: | Embryonic Stem Cell | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | <2KB | |
| Pubmed ID: | 25801169 |
| Enhancer experiment: | Luciferase Reporter Assay,ChIP-seq | |
| Enhancer experiment description: | We cloned individual constituent Enhancers of the five super-Enhancers into Enhancer-reporter vectors,and found that the majority (21/24) of super-Enhancer constituents were active in luciferase reporter assays (>1.5 fold over control, P<0.01 Student’s t-test) in ESCs . |
About Target gene
| Target gene : | Pou5f1(OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4) | |
| Strong evidence: | -- | |
| Less strong evidence: | Luciferase Reporter Assay,ChIP-seq | |
| Target gene experiment description: | We used the reporter system to investigate how various combinations of the constituents of the Pou5f1 super-enhancer behaved in this assay. The Pou5f1 super-enhancer was selected for this experiment because its SE was small enough to be fully accommodated by the reporter vector. The results revealed that the three constituent enhancers produced slightly less activity than E2 alone, which produced the largest signal. |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
