About Enhancer
| Enhancer ID: | E_02_252 | |
| Enhancer symbol: | STAT5 Enhancers | |
| Species: | Mouse | |
| Position : | chr11:100854851-100856851   |
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| Biosample name: | Mammary | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 30328555 |
| Enhancer experiment: | ChIP-seq,CRISPR/Cas9 | |
| Enhancer experiment description: | Autoregulation of the Stat5 locus in mammary tissue. a ChIP-seq profiles of an auto-regulatory Enhancer at the Stat5 locus. Mammary-specific STAT5 binding coincides with two adjacent GAS motifs,3.5 kb upstream of Stat5a. |
About Target gene
| Target gene : | Stat5a(AA959963,STAT5) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq | |
| Target gene experiment description: | We have further provided biological evidence supporting the in vivo function of a STAT5-driven super_x0002_enhancer with the aid of CRISPR/Cas9 genome editing.Finally, we discuss how the functions of mammary-specific super_x0002_enhancers are confined by the zinc finger protein, CTCF, to allow exclusive activation of mammary-specific genes without affecting common neighboring genes. |
About TF
| TF name : | Stat5a(AA959963,STAT5) | |
| TF experiment: | ChIP-seq,CRISPR/Cas9 | |
| TF experiment description: | We have further provided biological evidence supporting the in vivo function of a STAT5-driven super-Enhancer with the aid of CRISPR/Cas9 genome editing. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
