Enhancer ID: | E_02_202 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr16:92625802-92627802 |
|
Biosample name: | HPC-7 | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | Leukaemia | |
DO: | -- | |
Mesh: | D007938 | |
Distance from TSS: | >2KB | |
Pubmed ID: | 29042628 |
Enhancer experiment: | 4C-seq,ChIP | |
Enhancer experiment description: | 4C-seq in HPC-7 cells using the P1 and P2 promoters and the +24 enhancer as ‘baits’ identified genomic interactions at Runx1 (Fig. 1a) |
Target gene : | Runx1(BTEB2,CKLF,IKLF) | |
Strong evidence: | 4C-seq | |
Less strong evidence: | -- | |
Target gene experiment description: | Strikingly, the +24 enhancer in particular forms many significant interactions outside the Runx1 domain (Fig. 1b,d). Many of these long-range interactions are with other genes or gene promoters on mouse chromosome 16 (Fig. 2). |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | known haematopoietic enhancers that are likely to be involved in regulating Runx1 expression in haematopoietic progenitor cells. |
Enhancer function experiment: | DNase I Hypersensitivity Assay,4C-seq,Hi-C |
Enhancer function experiment description: |
These regions not only drive haematopoietic expression, but also physically connect with the Runx1-P1 promoter, lending confidence to the concept that they are bona fide regulators of Runx1 transcription. |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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