About Enhancer
| Enhancer ID: | E_02_183 | |
| Enhancer symbol: | Id2 Enhancer | |
| Species: | Mouse | |
| Position : | chr12:25090158-25096935   |
|
| Biosample name: | Apoptotic Cell | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | Colorectal Carcinoma | |
| DO: | DOID:0080199 | |
| Mesh: | D015179 | |
| Distance from TSS: | <2KB | |
| Pubmed ID: | 26163528 |
| Enhancer experiment: | Luciferase Reporter Assay | |
| Enhancer experiment description: | To test this Tcf4 binding region for enhancer activity, we conducted luciferase reporter assays using the constructs shown in Fig. 1F. The putative Id2-enhancer fragment significantly activated Wnt-signaling dependent transcription from the CMV minimal promoter in two colorectal cancer cell lines (HCT116 and SW480) (Fig. 1G). Therefore, these results indicate that Id2 expression is stimulated by Wnt signaling through the enhancer region, in tumor epithelial cells of ApcΔ716 mice at an early stage of tumorigenesis. |
About Target gene
| Target gene : | Id2(GIG8,ID2A,ID2H,bHLHb26) | |
| Strong evidence: | -- | |
| Less strong evidence: | Luciferase Reporter Assay | |
| Target gene experiment description: | Schematic representation of theLuciferase (Luciferase) expression constructs containing the Id2 Enhancer with/without a CMV-minimal promoter. |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
