About Enhancer
| Enhancer ID: | E_02_166 | |
| Enhancer symbol: | E8II Enhancer | |
| Species: | Mouse | |
| Position : | chr6:71321750-71323696   |
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| Biosample name: | P5424 | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | <2KB | |
| Pubmed ID: | 26673693 |
| Enhancer experiment: | ChIP-seq,ChIP | |
| Enhancer experiment description: | We found that eRNAs essentially reca_x0002_pitulated Pol II patterns during DN to DP transition as wellas those of Ets1 in DP only, suggesting highest enhancer ac_x0002_tivity in class 4 at the DN stage and classes 4–5 at the DP stage (Figure 3C). Thus, distal Ets1 enhancers broadly re_x0002_cruit Pol II that is able to generate paused transcripts.Significance of gene expression differences by increasing Ets1-fold change. Expression fold changes for all classes, shown as a boxplot. Significance levels for each comparison are indicated above, with 1 star denoting P < 0.05, 2 stars denoting P < 0.01 and 3 stars denoting P < 0.005. |
About Target gene
| Target gene : | Cd8b1(Cd8b,Ly-3,Ly-C,Lyt-3) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq,Western blot,ChIP-qPCR | |
| Target gene experiment description: | As exemplified at the E8II Enhancer of the Cd8 locus, and at the Tcra and Tcrb Enhancers,Ets1 in fact seemed to recruit Pol II as well as promoting High throughputer H3K4me3 in some cases. |
About TF
| TF name : | Ets1(ETS-1,EWSR2,c-ets-1,p54)Tcf1Runx1(AML1,AML1-EVI-1,AMLCR1,CBF2alpha,CBFA2,EVI-1,PEBP2aB,PEBP2alpha) | |
| TF experiment: | ChIP-qPCR | |
| TF experiment description: | We further validated the dynamic recruitment of TCF1 and Runx1 by ChIP-qPCR at the Tcra Enhancer,which is bound by similar levels of Ets1in both DN and DP thymocytes. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
