About Enhancer
| Enhancer ID: | E_02_155 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr6:122653828-122675804   |
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| Biosample name: | Mouse Embryonic Stem Cell | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 26550034 |
| Enhancer experiment: | ChIP-seq,ChIP | |
| Enhancer experiment description: | The genome-wide mapping of Tip60 binding in mESCs by chromatin immunoprecipitation (ChIP) coupled with high-throughput sequencing (ChIP-seq) shows that the Tip60 complex is present at promoter regions of predominantly active genes that are bound by RNA polymerase II (Pol II) and contain the H3K4me3 histone mark. The coactivator HAT complexes, Tip60- and Mof (KAT8)- containing (NSL and MSL), show a global overlap at promoters, whereas distinct binding profiles at enhancers suggest different regulatory functions of each essential HAT complex. Interestingly, Tip60 enrichment peaks at about 200 bp downstream of the transcription start sites suggesting a function for the Tip60 complexes in addition to histone acetylation. |
About Target gene
| Target gene : | Nanog(NANOG) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq | |
| Target gene experiment description: | As two of the so-called ‘super Enhancer’ regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig. 7a, b). |
About TF
| TF name : | Myc(MRTLC,bHLHe39,c-Myc,MYC)Stat3(ADMIO,ADMIO1,APRF,HIES)Nfkb1(CVID12,EBP-1,KBF1,NF-kB,NF-kB1,NF-kappa-B1,NF-kappaB,NFKB-p105,NFKB-p50,NFkappaB,p105,p50)E2f1(E2F-1,RBAP1,RBBP3,RBP3)Trp53 | |
| TF experiment: | ChIP-seq | |
| TF experiment description: | Mammalian Tip60 has been described as a transcriptional co-activator complex that is supposed to mediate the action of large variety of transcription factors,including nuclear receptors,c-Myc,STAT3,NF-kappaB,E2F1,p55 and others.To further address the global distribution and function of the Tip60 complex in mESCs, we compared high-confidence Tip60 binding sites with marks, which are either associated with active transcription at promoters (Pol II and H3K4me3) or enriched at enhancer sites (H3K4me1 and H3K27ac). |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
