About Enhancer
| Enhancer ID: | E_02_151 | |
| Enhancer symbol: | Nodal Enhancer (NDE) | |
| Species: | Mouse | |
| Position : | chr10:61402781-61405448   |
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| Biosample name: | Embryonic Stem Cell | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 26494787 |
| Enhancer experiment: | ChIP,ChIP-seq | |
| Enhancer experiment description: | ChIP (red) and input (blue) wiggle plot overlays showing enrichment of Lhx1 ChIP-seq density at Hesx1,Fzd8,Embigin,Nodal,Otx2,and Foxa3. Purple boxes indicate the positions of previously mapped Nodal Enhancer elements. |
About Target gene
| Target gene : | Nodal(Tg.413d) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP,ChIP-seq | |
| Target gene experiment description: | Conditional inactivation of Lhx1 dis_x0002_rupts anterior definitive endoderm development and impedes node and midline morphogenesis in part due to severe disturbances in visceral endoderm displacement. Transcriptional profiling and ChIP-seq (chromatin immunopre_x0002_cipitation [ChIP] followed by high-throughput sequencing) experiments identified Lhx1 target genes, including numerous anterior definitive endoderm markers and components of the Wnt signaling pathway. Interestingly, Lhx1-binding sites were enriched at enhancers, including the Nodal-proximal epiblast enhancer element and enhancer regions controlling Otx2 and Foxa2 expression. |
About TF
| TF name : | Lhx1(Lim1)Eomes(C77258,TBR-2,Tbr2) | |
| TF experiment: | ChIP | |
| TF experiment description: | Several putative Lhx1 target genes were represented in our ChIP data set. For example, Lhx1 binding was detected at two distinct regions at the Hesx1 locus, including a regulatory element in the 5′ untranslated region (containing two Lhx1-binding motifs) and a 3′ distal enhancer. Lhx1 ChIP peaks were also present upstream of Embigin exon 1. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
