About Enhancer
| Enhancer ID: | E_02_146 | |
| Enhancer symbol: | AHF Enhancer | |
| Species: | Mouse | |
| Position : | chr13:83661050-83662862   |
|
| Biosample name: | Embryonic Stem Cell | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | Heart Failure | |
| DO: | -- | |
| Mesh: | D006333 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 26321200 |
| Enhancer experiment: | 3C-qPCR,3C-seq | |
| Enhancer experiment description: | Multiple promoter-interacting elements were detected in the Mef2c lo_x0002_cus, of which some showed a lower signal in Ldb1-deficientEBs (Figure 5B). Importantly, we observed interactions of the AHF enhancer with the promoter area and with the 30 end of the Mef2c gene, which were decreased in Ldb1-deficient EBs(Figure 5B). 3C-qPCR experiments revealed a similar long-range interaction pattern in WT versus Ldb1-/-EBs during the course of cardiac differentiation and in dissected SHF and hearts of E8–10.5 embryos, confirming the 3C-seq results (Figure 5C). |
About Target gene
| Target gene : | Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2) | |
| Strong evidence: | 3C-qPCR,3C-seq | |
| Less strong evidence: | -- | |
| Target gene experiment description: | Multiple promoter-interacting elements were detected in the Mef2c lo_x0002_cus, of which some showed a lower signal in Ldb1-deficientEBs (Figure 5B). Importantly, we observed interactions of the AHF enhancer with the promoter area and with the 30 end of the Mef2c gene, which were decreased in Ldb1-deficient EBs(Figure 5B). 3C-qPCR experiments revealed a similar long-range interaction pattern in WT versus Ldb1-/-EBs during the course of cardiac differentiation and in dissected SHF and hearts of E8–10.5 embryos, confirming the 3C-seq results (Figure 5C). |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
