About Enhancer
| Enhancer ID: |
|
E_02_129 |
| Enhancer symbol: |
|
Ucp1 Enhancer |
| Species: |
|
Mouse |
| Position : |
|
chr8:83287848-83288068
   |
| Biosample name: |
|
Brown Fat Cell |
| Experiment class : |
|
Low throughput |
| Enhancer type: |
|
Enhancer |
| Disease: |
|
-- |
| DO: |
|
-- |
| Mesh: |
|
-- |
| Distance from TSS: |
|
>2KB |
| Pubmed ID: |
|
25644605 |
| Enhancer experiment: |
|
ChIP,RT-PCR |
| Enhancer experiment description: |
|
we hypothesized that PRDM16 might be recruited to the enhancer region of the Ucp1 gene through the interaction with PGC-1a. This possibility was tested in an immobilized template assay with purified proteins and a beadimmobilized DNA fragment spanning the 220-bp Ucp1 enhancer. |
About Target gene
| Target gene : |
|
Ucp1(AI385626,Slc25a7,Ucp) |
| Strong evidence: |
|
-- |
| Less strong evidence: |
|
ChIP,RT-PCR |
| Target gene experiment description: |
|
Overall, these results indicate that the ZF1 domain is required for the recruitment of PRDM16 to the Ucp1 enhancer through MED1 and PGC-1a. |
About TF
| TF name : |
|
Prdm16(5730557K01Rik,csp1,mel1) |
| TF experiment: |
|
ChIP |
| TF experiment description: |
|
To determine whether PRDM16 is recruited to the Enhancer following Ucp1 induction, we treated Med1 +/+MEFs that stably express PPARg and PRDM16 with forskolin and performed a chromatin immunoprecipitation (ChIP) assay with an antibody specific for PRDM16. |
About Function
| Enhancer function : |
-- |
| Enhancer function experiment: |
-- |
Enhancer function
experiment description: |
-- |
About SNP
| SNP ID: |
|
-- |
| SNP position: |
|
-- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs
