Enhancer ID: | E_02_058 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr6:122727606-122727632 |
|
Biosample name: | N2a | |
Experiment class : | Low throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | <2KB | |
Pubmed ID: | 23321477 |
Enhancer experiment: | Transfection,Luciferase Reporter Assay,PCR,EMSA,ChIP | |
Enhancer experiment description: | Transient transfection assays in N2A neuroblasts using murine glut3-luciferase reporter constructs mapped the hypoxia-induced enhancer activities to -857- to -573-bp and -203- to -177-bp regions. |
Target gene : | Slc2a3(GLUT3) | |
Strong evidence: | -- | |
Less strong evidence: | ChIP | |
Target gene experiment description: | Hypoxia-exposed N2A nuclear extracts demonstrated an increase in HIF-1a and p-Creb binding to HRE (-828 to -824 bp) and AP-1 (-187 to -180 bp) cis-elements, respectively, in electromobility shift and supershift assays, which was confirmed by chromatin immunoprecipitation assays. |
TF name : | Hif1a(HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8,bHLHe78)Creb1(2310001E10Rik,3526402H21Rik,AV083133,Creb,Creb-1) | |
TF experiment: | ChIP,EMSA | |
TF experiment description: | Hypoxia-exposed N2A nuclear extracts demonstrated an increase in HIF-1α and p-Creb binding to HRE (-828 to -824 bp) and AP-1 (-187 to -180 bp) cis-elements, respectively, in electromobility shift and supershift assays, which was confirmed by chromatin immunoprecipitation assays. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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