About Enhancer
| Enhancer ID: | E_01_418 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr5:172196326-172199378   |
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| Biosample name: | MCF-7,MDA-MB-231 | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | Breast Cancer | |
| DO: | DOID:1612 | |
| Mesh: | D001943 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 26859151 |
| Enhancer experiment: | ChIP-seq | |
| Enhancer experiment description: | Similar co-localisation studies were conducted in MDA-MB-231 cells to further understand the potential contribution of DUSP family members in the mesenchymal state. Similar to above, DUSP1 showed high levels of co-localization with the active promoter marks H3K9me1 (PCC = 0.65) and H3K4me3 (PCC = 0.72) (Fig 2E), while DUSP4 showed definite co-localisa_x0002_tion with the enhancer marks H3K27ac (PCC = 0.56) and strong co-localisation with H3K4me1 (PCC = 0.78) (Fig 2F) but not H3K4me3 or H3K9me3 (Fig C in S2 Fig). |
About Target gene
| Target gene : | DUSP1(CL100,HVH1,MKP-1,MKP1,PTPN10) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP,RT-qPCR | |
| Target gene experiment description: | Interestingly, we found that siRNA-mediated knockdown of DUSP1 and DUSP4 does not affect the expression of these genes (data not shown). Taken together,these data indicate a novel chromatin-anchored role for DUSP1 and DUSP4 in mesenchymal breast cancer cells. |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
