About Enhancer
| Enhancer ID: | E_01_406 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr9:91737604-92057238   |
|
| Biosample name: | Primary Human BJ Fibroblasts | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | -- | |
| Pubmed ID: | 26776159 |
| Enhancer experiment: | Luciferase Reporter Assay,ChIP-qPCR,GRO-seq,ChIP-seq,4C | |
| Enhancer experiment description: | Thus,we assessed whether p53BERs can induce lincRNAs with essential roles within the p53 pathway. We first genome-wide mapped p53BERs using both publically available p53 chromatin immuno_x0002_precipitation sequencing (ChIP-seq) data sets10 and enhancer domains epigenetically defined by the Broad Institute segmentation. |
About Target gene
| Target gene : | lincRNA00475 | |
| Strong evidence: | 4C | |
| Less strong evidence: | -- | |
| Target gene experiment description: | we identified and characterized a novel p53-bound intronic enhancer that controls the expression of its host, the lincRNA00475(linc-475). We demonstrate the requirement of linc-475 for the proper induction of a p53-dependent cell cycle inhibitory response. |
About TF
| TF name : | CTCF(MRD21)TP53(BCC7,BMFS5,LFS1,P53,TRP53) | |
| TF experiment: | ChIP-qPCR | |
| TF experiment description: | In addition,we assessed whether CTCF could influence the p53-dependent regulation of linc-475. To tackle this question, we first evaluated and confirmed the binding of CTCF upstream of linc-475 using ChIP–quantitative PCR.Next, we tested whether knocking down CTCF could interfere with the expression levels of linc-475. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
