About Enhancer
| Enhancer ID: |
|
E_01_404 |
| Enhancer symbol: |
|
PRE |
| Species: |
|
Human |
| Position : |
|
chr1:67739940-67741075
   |
| Biosample name: |
|
GM12878,Th17,Th1 |
| Experiment class : |
|
Low throughput |
| Enhancer type: |
|
enhancer |
| Disease: |
|
Ankylosing Spondylitis |
| DO: |
|
DOID:7147 |
| Mesh: |
|
D013167 |
| Distance from TSS: |
|
-- |
| Pubmed ID: |
|
26919345 |
| Enhancer experiment: |
|
DNase I Hypersensitivity Assay |
| Enhancer experiment description: |
|
We identified a PRE (Chr1:67739940–67741075) located 14.2 kb downstream of IL23R and 33.1 kb upstream of IL12RB2.This region is DNase I hypersensitive (in Th1--cells, but not Th17--cells) and exhibits TF binding (lymphoblastoid cell--line; GM12878) and enhancer--associated H3K4me1 methylation (CD4+ CD25− IL--17A− T--cells; PMA and ionomycin--stimulated). |
About Target gene
| Target gene : |
|
IL23R-IL12RB2 |
| Strong evidence: |
|
-- |
| Less strong evidence: |
|
DNase I Hypersensitivity Assay |
| Target gene experiment description: |
|
We identified a PRE (Chr1:67739940–67741075) located 14.2 kb downstream of IL23R and 33.1 kb upstream of IL12RB2.This region is DNase I hypersensitive (in Th1-cells, but not Th17-cells) and exhibits TF binding (lymphoblastoid cell-line; GM12878) and enhancer-associated H3K4me1 methylation (CD4+ CD25− IL-17A− T-cells; PMA and ionomycin-stimulated). |
About TF
| TF name : |
|
-- |
| TF experiment: |
|
-- |
| TF experiment description: |
|
-- |
About Function
| Enhancer function : |
-- |
| Enhancer function experiment: |
-- |
Enhancer function
experiment description: |
-- |
About SNP
| SNP experiment: |
|
DNase I Hypersensitivity Assay,ChIP-qPCR,Luciferase Reporter Assay |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs
