About Enhancer
Enhancer ID: |
|
E_01_378 |
Enhancer symbol: |
|
PRE |
Species: |
|
Human |
Position : |
|
chr1:67739940-67741075
|
Biosample name: |
|
Lymphoblastoid Cell Lines |
Experiment class : |
|
low throughput |
Enhancer type: |
|
enhancer |
Disease: |
|
Ankylosing Spondylitis |
DO: |
|
DOID:7147 |
Mesh: |
|
D013167 |
Distance from TSS: |
|
>2kb |
Pubmed ID: |
|
26916345 |
Enhancer experiment: |
|
DNase I Hypersensitivity Assay |
Enhancer experiment description: |
|
We identified a PRE (Chr1:67739940–67741075) located 14.2 kb downstream of IL23R and 33.1 kb upstream of IL12RB2.This region is DNase I hypersensitive (in Th1-cells, but not Th17-cells) and exhibits TF binding (lymphoblastoid cell line; GM12878) and enhancer-associated H3K4me1 methylation (CD4+ CD25− IL-17A− T-cells; PMA and ionomycin-stimulated). |
About Target gene
Target gene : |
|
IL23R(IL23R) |
Strong evidence: |
|
-- |
Less strong evidence: |
|
DNase I Hypersensitivity Assay |
Target gene experiment description: |
|
We identified a PRE (Chr1:67739940–67741075) located 14.2 kb downstream of IL23R and 33.1 kb upstream of IL12RB2.This region is DNase I hypersensitive (in Th1-cells, but not Th17-cells) and exhibits TF binding (lymphoblastoid cell line; GM12878) and enhancer-associated H3K4me1 methylation (CD4+ CD25− IL-17A− T-cells; PMA and ionomycin-stimulated). |
About TF
TF name : |
|
-- |
TF experiment: |
|
-- |
TF experiment description: |
|
-- |
About Function
Enhancer function : |
-- |
Enhancer function experiment: |
-- |
Enhancer function experiment description: |
-- |
About SNP
SNP experiment: |
|
DNase I Hypersensitivity Assay,Luciferase Reporter Assay |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs