About Enhancer
| Enhancer ID: |
|
E_01_365 |
| Enhancer symbol: |
|
-- |
| Species: |
|
Human |
| Position : |
|
chr20:21452815-21462458
   |
| Biosample name: |
|
HeLa,293T |
| Experiment class : |
|
Low+High throughput |
| Enhancer experiment: |
|
ChIP-seq,PCR,3C |
| Enhancer experiment description: |
|
WDR5 occupancy at activated EWS-FLI1 sites in SKNMC and A673 cells was also detected by ChIP-seq. Accordingly, ChIP-seq profiling of MSCs before and after fusion gene induction demonstrated that EWS-FLI1 recruits WDR5 to activated enhancers. |
About Target gene
| Target gene : |
|
NKX2-2(NKX2.2,NKX2B) |
| Strong evidence: |
|
3C |
| Less strong evidence: |
|
PCR |
| Target gene experiment description: |
|
Genes proximal to EWS-FLI1 bound Enhancers include known regulators with critical functions in Ewing sarcoma,such as CCND1 and NKX2-2,as well as many novel targets. |
About TF
| TF name : |
|
ELF1(EFTUD1,RIA1) |
| TF experiment: |
|
ChIP-seq |
| TF experiment description: |
|
We focused on the ETS-related transcription factor ELF1,which has similar sequence preference to FLI1 and is expressed in A673 and SKNMC cells. We surveyed ELF1 binding in SKNMC cells by ChIP-seq before and after EWS-FLI1 knock-down. |
About Function
| Enhancer function : |
-- |
| Enhancer function experiment: |
-- |
Enhancer function
experiment description: |
-- |
About SNP
| SNP ID: |
|
-- |
| SNP position: |
|
-- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs
