About Enhancer
| Enhancer ID: |
|
E_01_272 |
| Enhancer symbol: |
|
-- |
| Species: |
|
Human |
| Position : |
|
chr11:17666830-17677080
   |
| Biosample name: |
|
Human Fibroblast Cell Lines |
| Experiment class : |
|
Low+High throughput |
| Enhancer type: |
|
Super-Enhancer |
| Disease: |
|
Alveolar Rhabdomyosarcoma |
| DO: |
|
DOID:4051 |
| Mesh: |
|
D018232 |
| Distance from TSS: |
|
>2KB |
| Pubmed ID: |
|
28446439 |
| Enhancer experiment: |
|
ChIP-seq,4C,Luciferase Reporter Assay |
| Enhancer experiment description: |
|
We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET |
About Target gene
| Target gene : |
|
MYOD1(MYF3,MYOD,PUM,bHLHc1) |
| Strong evidence: |
|
4C |
| Less strong evidence: |
|
ChIP-seq,Luciferase Reporter Assay |
| Target gene experiment description: |
|
We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET |
About TF
| TF name : |
|
PAX3(CDHS,HUP2,WS1,WS3)FOXO1(FKH1,FKHRA,FOXO1) |
| TF experiment: |
|
ChIP-qPCR,ChIP-seq |
| TF experiment description: |
|
To gain insight into the epigenetic consequences of PAX3-FOXO1, we mapped the landscape of active and repressive histone marks by sequencing DNA enriched by chromatin immunoprecipitation (ChIP-seq) from a patient derived fusion positive FP-RMS cell line RH4.
|
About Function
| Enhancer function : |
-- |
| Enhancer function experiment: |
-- |
Enhancer function
experiment description: |
-- |
About SNP
| SNP ID: |
|
-- |
| SNP position: |
|
-- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs
