Enhancer ID: | E_01_215 | |
Enhancer symbol: | PROX1-11 Enhancer | |
Species: | Human | |
Position : | chr1:214150511-214151337 |
|
Biosample name: | K-562 | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | Lymphedema | |
DO: | DOID:4977 | |
Mesh: | D008209 | |
Distance from TSS: | >2KB | |
Pubmed ID: | 26214525 |
Enhancer experiment: | ChIP-seq,Luciferase Reporter Assay | |
Enhancer experiment description: | The –11 kb element was also cloned distally into the enhancer site of pGL4.12, together with a subcloned region of the Prox1 +4.5 kb element (containing GATA sites 4 and 5, see Methods for details) acting as a promoter. This addition resulted in a significant increase in luciferase activity, demonstrating that the Prox1 –11 kb element is capable of acting as an enhancer (Figure 1D). |
Target gene : | PROX1(PROX1) | |
Strong evidence: | -- | |
Less strong evidence: | Luciferase Reporter Assay | |
Target gene experiment description: | The –11 kb element was also cloned distally into the enhancer site of pGL4.12, together with a subcloned region of the Prox1 +4.5 kb element (containing GATA sites 4 and 5, see Methods for details) acting as a promoter. This addition resulted in a significant increase in luciferase activity, demonstrating that the Prox1 –11 kb element is capable of acting as an enhancer (Figure 1D). |
TF name : | GATA2(DCML,IMD21,MONOMAC,NFE1B)FOXC2(FKHL14,LD,MFH-1,MFH1)NFATC1(NF-ATC,NF-ATc1.2,NFAT2,NFATc) | |
TF experiment: | ChIP | |
TF experiment description: | ChIP demonstrates that GATA2, FOXC2, and NFATC1 ChIP at the PROX1 –11 kb enhancer in LECs and BECs, but not K-562 cells. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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